不同癌变组织太赫兹光谱及其比较研究

发布时间：2018-06-03 11:25

本文选题：太赫兹时域光谱 + 比较研究　；参考：《天津大学》2012年硕士论文

【摘要】：近年来太赫兹时域光谱技术作为自然科学领域异军突起的一种新兴技术越来越受到人们的关注，尤其是在生物医学领域，科学工作者寄希望于该技术能够更好的在肿瘤诊断、烧伤治疗等领域发挥作用，造福人类。本课题的目的在于运用太赫兹时域光谱技术对生物医学领域中常见的恶性癌变组织进行诊断研究，在实验技术和理论分析方面积累经验，缩小与国外同类别研究的差距。比较研究主要体现在：实验方式分为透射式和反射式；实验对象分为石蜡封装的基底细胞癌组织和新鲜癌变组织。本课题总结了太赫兹技术在生物医学领域的应用，包括太赫兹辐射效应、太赫兹光谱技术和太赫兹成像技术。在了解皮肤结构和组成物质的基础上重点对组织中的水化作用展开了研究，引入了皮肤分层模型和Debye模型，，得到了不同状态下水在太赫兹频段的介电特性。通过透射式太赫兹时域光谱技术，运用1.3THz下的吸收系数获得了基底细胞癌样品的图像，并从病理学的角度给予解读，获得了癌变区域和健康区域的复介电常数。同时运用MATLAB和LabVIEW混合编程设计了不同方法的成像界面。反射式太赫兹时域光谱技术的实验研究也取得了进展。搭建了自行设计的光纤化的反射式实验系统，论证了系统搭建过程中透镜及参数的选择，光纤色散及补偿问题，系统的频谱宽度为0.15～1.2THz，光斑直径为3mm，满足测量要求。同时对新鲜健康皮肤组织、脂肪瘤组织、基底细胞癌组织开展了研究，得到了区分度明显的吸收系数谱线。在反射式光纤化系统搭建和实验方法技巧方面积累了经验。使用统计学方法-判别分析实现了对癌变区域和健康区域正确的区别，实现了定量检测，为将来太赫兹时域光谱技术用于医学临床奠定了基础。
[Abstract]:In recent years, terahertz time-domain spectroscopy (THz), as an emerging technology in the field of natural science, has attracted more and more attention, especially in the field of biomedicine. Burn treatment and other fields play a role in the benefit of mankind. The purpose of this paper is to use THz time domain spectroscopy to diagnose malignant cancerous tissues in biomedical field, accumulate experience in experimental technology and theoretical analysis, and narrow the gap with the same kind of research abroad. The comparative studies are as follows: the experimental methods are transmissive and reflex, and the experimental objects are paraffin encapsulated basal cell carcinoma and fresh cancerous tissue. This paper summarizes the applications of terahertz technology in biomedical fields, including terahertz radiation effect, terahertz spectroscopy and terahertz imaging technology. Based on the understanding of skin structure and composition, the hydration in tissues was studied. Skin delamination model and Debye model were introduced, and the dielectric properties of water in different states at terahertz band were obtained. By using the transmission terahertz time-domain spectroscopy (THz), the image of basal cell carcinoma (BCC) samples was obtained by using the absorption coefficient under 1.3THz, and the complex permittivity of cancerous and healthy regions was obtained from the point of view of pathology. At the same time, the imaging interface of different methods is designed by mixed programming of MATLAB and LabVIEW. Progress has also been made in the experimental study of reflective terahertz time domain spectroscopy. A self-designed fiber-optic reflective experimental system is built, and the selection of lens and parameters, fiber dispersion and compensation are demonstrated. The spectrum width of the system is 0.151.2THZ, and the spot diameter is 3mm, which meets the measurement requirements. At the same time, fresh healthy skin tissue, lipoma tissue and basal cell carcinoma tissue were studied, and the distinct absorption coefficient lines were obtained. Experience has been accumulated in the construction of reflective fiber optic systems and the techniques of experimental methods. The use of statistical method-discriminant analysis to realize the correct distinction between cancerous and healthy regions, and to achieve quantitative detection, laid a foundation for the future use of terahertz time-domain spectroscopy in medical clinic.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R312

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