几种降脂减肥实验动物模型的建立与比较

发布时间：2018-06-04 19:03

本文选题：动物肥胖模型 + 造模方法　；参考：《中华中医药学刊》2017年07期

【摘要】：以肥胖及其相关的高血脂、动脉粥样硬化、高血压、糖尿病等组成的代谢综合征已成为危害人民健康的一组首要疾病,建立肥胖动物模型,对于研究肥胖及其相关疾病的发生、发展及其机制具有极为重要的意义。目前肥胖动物模型的建模方法有营养性肥胖、精神抑制药致肥胖、维生素D致肥胖、下丘脑损伤致肥胖、双侧卵巢切除致肥胖等。仅营养性肥胖动物模型就有小鼠、大鼠、豚鼠、地鼠、家兔等,建模评价指标有体增重率、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等。不同的肥胖动物模型,其模型动物、造模方法、肥胖指标高低及用途等均有较大差异,论文系统阐述了降脂减肥研究中常用肥胖动物模型的建模方法及其特点,为降脂减肥的研究提供参考。
[Abstract]:Metabolic syndrome consisting of obesity and its associated hyperlipidemia, atherosclerosis, hypertension and diabetes has become a group of major diseases that endanger people's health. The establishment of obese animal models is useful for the study of the occurrence of obesity and related diseases. Development and its mechanism are of great significance. At present, the modeling methods of obesity animal models include nutritional obesity, obesity caused by mental suppressants, obesity caused by vitamin D, obesity caused by hypothalamus injury, obesity caused by bilateral ovariectomies, and so on. There were mice, rats, guinea pigs, hamsters, rabbits and so on in nutritional obesity animal models. The indexes of modeling and evaluation included body weight gain rate, serum total cholesterol TCU, triglyceride TGN, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and so on. There are great differences among different obesity animal models, such as model animals, modeling methods, obesity indexes and their uses. This paper systematically describes the modeling methods and characteristics of obesity animal models commonly used in the research of reducing fat and reducing weight. To provide a reference for the study of reducing fat and reducing weight.
【作者单位】：云南中医学院中药学院;昆明理工大学;
【基金】：国家自然科学基金项目(21466037) 云南省教育厅科学研究重大专项项目(ZD2014009) 云南省应基-中医联合专项项目(U0120150242)
【分类号】：R-332;R589.2

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