谷胱甘肽硫转移酶K1研究进展

发布时间：2018-06-06 14:25

本文选题：谷胱甘肽硫转移酶K + 线粒体　；参考：《中南大学学报(医学版)》2017年04期

【摘要】：谷胱甘肽硫转移酶K1(glutathione S-transferase kappa 1,GSTK1)是一个参与脂联素分泌和多聚化的关键蛋白,且在线虫中已经证实,GSTK1与能量产生和脂质代谢有关。同时GSTK1表达水平与肥胖呈负相关,并能缓解内质网应激诱导的脂联素水平下降,而且人GSTK1启动子的多态性与胰岛素分泌和脂肪沉积有关,因此,GSTK1可能成为一个治疗胰岛素抵抗及其相关的代谢疾病潜在的药物新靶点。
[Abstract]:Glutathione S-transferase (GSTK1) is a key protein involved in adiponectin secretion and polymerization, and it has been proved in nematode that GSTK1 is related to energy production and lipid metabolism. At the same time, the expression of GSTK1 was negatively correlated with obesity, and could alleviate the decrease of adiponectin level induced by endoplasmic reticulum stress, and the polymorphism of human GSTK1 promoter was related to insulin secretion and fat deposition. Therefore, GSTK1 may be a potential new drug target for insulin resistance and related metabolic diseases.
【作者单位】：中南大学湘雅二医院肾内科中南大学肾脏病研究所;
【基金】：国家自然科学基金(81270812,81470960)~~
【分类号】：R3411

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