碎裂QRS波在大鼠心肌梗死模型中的价值探讨

发布时间：2018-06-11 14:32

本文选题：碎裂QRS波 + 急性心肌梗死　；参考：《安徽医科大学学报》2017年07期

【摘要】：建立大鼠心肌梗死模型,探讨碎裂QRS波在大鼠心肌梗死模型中的价值。40只大鼠分为假手术组和心梗组,两组大鼠均在相同条件下进行手术,心梗组开胸并结扎大鼠冠状动脉前降支建立心肌梗死模型,假手术组只穿线不接扎。记录结扎(或穿线)10 min和60 min及术后4周大鼠心电图并分析碎裂QRS波及Q波变化规律。术后4周留取心肌梗死区组织标本,进行HE染色。与假手术组相比,心梗组大鼠在10、60 min及术后4周出现碎裂QRS波次数明显增多(P0.01)。HE染色显示,心梗组部分心肌细胞排列紊乱,出现空泡变性。通过建立大鼠心肌梗死模型显示,碎裂QRS波可作为急性心肌梗死和陈旧性心梗诊断及预测疾病严重程度的新指标。
[Abstract]:To investigate the value of broken QRS wave in rat myocardial infarction model. Forty rats were divided into sham operation group and myocardial infarction group. The two groups were operated on under the same conditions. Myocardial infarction model was established in myocardial infarction group after thoracotomy and ligation of anterior descending coronary artery. The electrocardiogram (ECG) of 10 min and 60 min ligation (or suture) and 4 weeks after operation were recorded and the changes of fragmentation QRS and Q wave were analyzed. Tissue samples of myocardial infarction area were taken 4 weeks after operation and stained with HE. Compared with the sham-operated group, the number of broken QRS waves in myocardial infarction group increased significantly at 1060 min and 4 weeks after operation. The results of P0.01and HE staining showed that some myocardial cells in myocardial infarction group were disarranged and vacuolar degeneration occurred. A rat model of myocardial infarction showed that the broken QRS wave could be used as a new index to diagnose and predict the severity of acute myocardial infarction and old myocardial infarction.
【作者单位】：安徽医科大学第二附属医院心内科;安徽医科大学第二附属医院麻醉科;
【基金】：安徽省高校省级自然科学研究重大项目(编号:KJ2014Z016) 安徽医科大学校科研基金研究联合资助项目(编号:2015xkj113)
【分类号】：R-332;R542.22

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