生脉注射液3种成分在心肌缺血模型Beagle犬体内的药动学研究

发布时间：2018-06-13 19:14

本文选题：生脉注射液 + 人参皂苷Rg　；参考：《中国现代应用药学》2016年10期

【摘要】：目的研究生脉注射液活性成分人参皂苷Rg1、人参皂苷Re、五味子醇甲在正常和心肌缺血状态下Beagle犬体内的药动学变化。方法选用Agilent ZORBAX SB-C18色谱柱,流动相为乙腈-水,梯度洗脱,质谱采用选择反应监测(SIM)方式进行正离子检测3种活性成分。用Win Nonlin 6.3软件和SPSS 19.0软件计算各给药组药动学参数,并进行统计分析。结果造模后,人参皂苷Rg1半衰期缩短;人参皂苷Re表观分布容积增大,肾清除率减慢;模型组五味子醇甲半衰期延长,体内平均滞留时间延长,表观分布容积增大,肾清除率减慢。结论 Beagle犬滴注生脉注射液后,人参皂苷Rg1、人参皂苷Re、五味子醇甲在心肌缺血模型犬体内的药动学特征,与正常犬的药动学特征存在很大差异。
[Abstract]:Objective to investigate the pharmacokinetic changes of ginsenoside Rg1, ginsenoside Reand Schisandrin A in Beagle dogs under normal and myocardial ischemia conditions. Methods Agilent ZORBAX SB-C18 column was used. The mobile phase was acetonitrile-water gradient elution. The pharmacokinetic parameters of each group were calculated with win Nonlin 6.3 and SPSS 19.0 software, and the statistical analysis was carried out. Results the half-life of ginsenoside Rg1 was shortened, the apparent volume of ginsenoside re was increased, the renal clearance rate was slowed down, the half-life of Schisandrin A was prolonged, the average residence time was prolonged, and the volume of apparent distribution was increased in the model group. Renal clearance slowed down. Conclusion the pharmacokinetic characteristics of ginsenoside rg _ 1, ginsenoside Reand and Schisandrin A in dogs with myocardial ischemia were significantly different from those of normal dogs after beagle dogs were injected with Shengmai injection.
【作者单位】：辽宁省中医药研究院临床药理实验室;辽宁中医药大学药学院;
【基金】：国家“十二五”重大新药创制项目(2012ZX09303-017) 国家临床重点专科建设项目经费资助(2013年) 国家中医药管理局临床中药学重点学科(2009年) 辽宁中医药大学杏林学者青蓝工程(2013年)
【分类号】：R285.5;R-332

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