关于蛋白激酶C-γ及其在中枢中的作用的研究进展

发布时间：2018-06-22 19:45

本文选题：蛋白激酶C-γ + 长时程增强效应　；参考：《中华眼科医学杂志(电子版)》2016年01期

【摘要】：蛋白激酶C-γ是经典型蛋白激酶C家族中的一个亚型。作为蛋白激酶C家族中的一员,它具有蛋白激酶C的普遍作用,同时又具有其特异作用。在磷脂酰丝氨酸存在的情况下,蛋白激酶C-γ可被Ca~(2+)、磷脂酰甘油等激活。蛋白激酶C-γ具有神经特异性,主要在大脑皮层和脊髓的神经元中表达。cPKC-γ的缺失或突变是导致许多神经系统疾病的原因之一,可诱发原发性视网膜色素变性、白内障和脊髓小脑共济失调等疾病。异常视觉经验可通过神经发育可塑性影响视皮层发育最终导致弱视产生,作为一种神经特异性蛋白激酶,c PKC-γ是否在视觉发育可塑性中发挥作用,仍存在争议。本文中笔者主要从cPKC-γ的生物化学性质、分子作用机制和与其相关的疾病方面进行综述。
[Abstract]:Protein kinase C-纬 is a subtype of classical protein kinase C family. As a member of protein kinase C family, protein kinase C has both universal and specific effects. In the presence of phosphatidyl serine, protein kinase C- 纬 can be activated by Ca ~ (2) and phosphatidylglycerol. Protein kinase C- 纬 (PKC- 纬) is neurospecific. The deletion or mutation of protein kinase C- 纬 in neurons of cerebral cortex and spinal cord is one of the causes of many nervous system diseases, which can induce primary retinitis pigmentosa. Cataract and spinal cerebellum ataxia and other diseases. Abnormal visual experience can affect the development of visual cortex through neurodevelopmental plasticity and lead to amblyopia. As a kind of neuro-specific protein kinase c PKC- 纬, it is still controversial whether PKC- 纬 plays a role in visual development plasticity. In this paper, the biochemical properties, molecular mechanism and related diseases of cPKC- 纬 are reviewed.
【作者单位】：首都医科大学附属北京同仁医院北京同仁眼科中心
【基金】：国家自然科学基金项目(No.30600688) 北京市自然科学基金项目(No.7132057) 北京市优秀人才培养计划项目(No.2010D003034000007)
【分类号】：R363

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