锌指结构Osterix对骨骼发育影响的研究进展

发布时间：2018-06-22 18:23

本文选题：Osterix + 骨骼发育　；参考：《中国骨质疏松杂志》2016年03期

【摘要】：间充质细胞在骨化形成骨的过程中,其原基会分泌一些Hedgehog,Wnt和FGF家族和TGF-β的转录因子用于调控和起始早期骨骼相关基因的表达,研究这些早期调控因子对于研究期成骨代谢十分重要,锌指结构Osterix基因作为重要的成骨细胞特异性转录因子越来越被人们重视,研究其基因的作用及其相关的机制,利于我们进一步了解成骨代谢和成骨相关性疾病:本文围绕Osterix的发现和功能,Osterix对小鼠中骨骼发育和成骨细胞的影响,Osterix对人类中骨骼的发育影响的研究以及Osterix的突变与人类骨骼疾病的关系方面进行阐述。目前相关Osterix的综述多集中关注于其对成骨细胞功能的调控。本文主要集中在于对于Osterix在动物和人体骨骼发育的影响的相关报道,进而进一步了解Osterix与人类骨骼疾病的相关的关系。本综述旨在拓展了Osterix作为成骨细胞重要调控因子对于在体的动物和人类骨骼发育的认识。
[Abstract]:In the process of bone formation, mesenchymal cells secrete some Hedgehog, Wnt and FGF family and TGF- beta transcription factors to regulate and start the expression of early bone related genes. The study of these early regulators is very important for the study of osteoblast metabolism, and the zinc finger structure Osterix gene is an important osteoblast. The role of the heterosexual transcription factors is becoming more and more important. The study of the role of the gene and its related mechanisms will help us to further understand the osteoblast metabolism and osteogenic related diseases. This article focuses on the discovery and function of Osterix, the effect of Osterix on the bone development and osteoblasts in mice, and the effect of Osterix on the development of bone in human. The mutation of Osterix and the relationship between human bone disease and human skeletal disease is expounded. The current review of the related Osterix focuses on its regulation of osteoblast function. This article focuses on the related reports of the effects of Osterix on the development of bones in animals and human bones, and further to understand the relationship between Osterix and human skeletal disease. This review aims to expand the understanding of Osterix as an important regulatory factor of osteoblasts for animal and human skeletal development in vivo.
【作者单位】：无锡市第二人民医院骨科;苏州大学附属第二医院骨科;
【基金】：国家自然科学基金(81273090) 江苏省普通高校研究生科研创新计划项目(KYLX_1264)
【分类号】：R336

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