mtDNA拷贝数的生物学意义及其调控

发布时间：2018-06-26 14:00

本文选题：线粒体DNA拷贝数 + 细胞自噬　；参考：《中国生物化学与分子生物学报》2017年06期

【摘要】：线粒体是细胞能量和自由基代谢中心,并在细胞凋亡、钙调控、细胞周期和信号转导中发挥重要作用,维持线粒体功能正常对于细胞正常行使职能意义重大。线粒体的功能与线粒体DNA(mitochondrial DNA,mtDNA)的数量和质量紧密相关,mtDNA的数量即mtDNA拷贝数又受到mtDNA质量的影响,因此mtDNA拷贝数可作为线粒体功能的重要表征。mtDNA拷贝数变异引起线粒体功能紊乱,进而导致疾病发生。本文综述了mtDNA拷贝数变异与神经退行性疾病、心血管疾病、肿瘤等疾病的发生发展和个体衰老之间的关系,以及mtDNA复制转录相关因子、氧化应激、细胞自噬等因素介导mtDNA拷贝数变异的调控机制。以期为进一步深入探究mtDNA拷贝数调控的分子机制,以及未来治疗神经退行性疾病、肿瘤及延缓衰老等提供一定的理论基础。
[Abstract]:Mitochondria play an important role in cell apoptosis, calcium regulation, cell cycle and signal transduction. The function of mtDNA is closely related to the quantity and quality of mtDNA (mtDNA), that is, mtDNA copy number is affected by mtDNA quality, so mtDNA copy number can be used as an important characterization of mitochondrial function. MtDNA copy number variation can cause mitochondrial dysfunction. This in turn leads to disease. This paper reviews the relationship between mtDNA copy number variation and neurodegenerative diseases, cardiovascular diseases, tumours, and individual aging, as well as the transcription related factors of mtDNA replication, oxidative stress, and so on. The regulatory mechanism of mtDNA copy number variation mediated by autophagy and other factors. In order to further explore the molecular mechanism of mtDNA copy number regulation, as well as the future treatment of neurodegenerative diseases, tumors and delay aging and so on to provide a certain theoretical basis.
【作者单位】：国家烟草质量监督检验中心;中国科学院合肥物质科学研究院应用技术研究所;
【基金】：国家局重点项目(No.110201402037)资助~~
【分类号】：Q75;R3416

【相似文献】