中国大陆流行的风疹病毒的变异变迁规律研究

发布时间：2018-06-28 01:33

本文选题：风疹病毒 + 基因型　；参考：《病毒学报》2017年01期

【摘要】：从分子水平上探讨1999~2015年中国大陆流行的风疹病毒动态变异变迁规律。方法依据全国麻疹/风疹实验室网络的风疹病毒学监测数据,对1999~2015年中国流行风疹病毒进行分子进化分析。1999~2015年从全国29个省市(除新疆和西藏外)共获得风疹病毒株1737株,分属于4个基因型(1E,1F,2A和2B基因型):11E基因型风疹病毒自2001年首次分离到之后,替代1F基因型风疹病毒成为2001~2013年中国流行风疹病毒的优势基因型,并从年代上可分为两个进化分支[Cluster A(2004-2015)和Cluster B(2001-2009)],然而自2011年其检出比例逐渐下降,至2015年该比例仅为1.3%;21F基因型风疹病毒在地理上局限于中国,而在2002年之后未再监测到,推测其在中国的传播可能已被阻断;32A基因型风疹病毒株均来自于疫苗相关病例;42000~2015年间中国至少有4个不同的2B基因型风疹病毒传播链(Lineage1-4),2B基因型风疹病毒在2010年之前只有零星的流行,一直处于弱势,但自2011年输入型2B基因型风疹病毒(Lineage 3)的检出构成比逐年增高,并在2014~2015年成为中国流行风疹病毒的主要基因型。通过对中国连续16年风疹病毒变异变迁规律的研究,系统地掌握了其进化和流行规律,同时也为中国风疹控制和将来消除提供了重要的病毒学监测数据。
[Abstract]:The dynamic variation of rubella virus in China from 1999 to 2015 was studied at molecular level. Methods according to the data of rubella virology surveillance of the national measles / rubella laboratory network, 1737 rubella virus strains were obtained from 29 provinces and cities (except Xinjiang and Tibet) from 1999 to 2015 by molecular evolution analysis of rubella virus in China from 1999 to 2015. The rubella virus of 1: 11e gene was isolated from four genotypes (1EO1FN2A and 2B), and the substitution of rubella virus of genotype 1F became the dominant genotype of rubella virus in China from 2001 to 2013. It can be divided into two evolutionary branches [Cluster A (2004-2015) and Cluster B (2001-2009)]. However, from 2011 to 2015, the proportion of rubella virus of the 21F genotype was only 1.33%, which was geographically confined to China, but was not detected after 2002. It is speculated that its transmission in China may have been blocked. The rubella virus strains all come from vaccine-related cases. During 2015, there are at least four different rubella virus genotypes (Lineage1-4) of rubella virus of type 2B in China in 2010. Before only a sporadic fashion, The detection ratio of rubella virus (Lineage 3), an imported type 2B genotype, has been increasing year by year since 2011, and has become the main genotype of rubella virus in China from 2014 to 2015. Based on the study of the variation of rubella virus in China for 16 consecutive years, the evolution and prevalence of rubella virus were systematically grasped, and the virological monitoring data were provided for the control and elimination of rubella in China in the future.
【作者单位】：中国疾病预防控制中心病毒病预防控制所卫生部医学病毒学和病毒病重点实验室世界卫生组织西太平洋区麻疹/风疹参比实验室;安徽理工大学医学院;北华大学附属医院;
【基金】：国家重点研发计划(项目号:2016YFC1200905);题目:重要新发突发病原体应急处置方案与规范研究国家自然科学基金课题(项目号:81101244);题目:我国流行风疹病毒的基因特征及其与疫苗株抗原性差异的研究十二五国家科技重大专项(项目号:2013ZXl0004—202);题目:病毒性传染病病原谱流行规律及变异研究国际合作课题(WPCHN1409379);题目:行使WHO西太区地区麻疹风疹参比实验室职能
【分类号】：R373.11

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