VEG株弓形虫卵囊对昆明小鼠的毒力研究

发布时间：2018-07-22 13:13

【摘要】：目的探究VEG株弓形虫卵囊对中国昆明小鼠的致病性。方法分别选择1个,100个~108个的VEG株弓形虫卵囊灌胃昆明小鼠,采用MAT、HE和IHC方法研究小鼠对弓形虫的感染情况,并分析小鼠感染率,生存率及其大脑内的弓形虫包囊数量。结果≥10~2个VEG株弓形虫卵囊可引起小鼠100%感染,最低致死剂量为10~2个卵囊,100%致死剂量为108个卵囊,急性期死亡时间为7DPI~14DPI,弓形虫的成囊率是32.14%(9/28),包囊数量为9~857个/只小鼠大脑,感染小鼠生存率为67.44%(29/43),最长存活时间≥390DPI。结论 VEG株弓形虫卵囊对昆明小鼠的毒力中等,包囊形成率较高。
[Abstract]:Objective to investigate the pathogenicity of toxoplasma gondii oocysts of VEG strain on Kunming mice. Methods one or 100 ~ 108 VEG strains of Toxoplasma gondii oocysts were gavaged to Kunming mice. The infection rate, survival rate and the number of Toxoplasma gondii cyst in the brain were analyzed by MATHE-HE and IHC methods. Results Toxoplasma gondii oocysts of 鈮，

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