我国六省市腮腺炎病毒引起的脑炎脑膜炎构成及其流行特征分析

发布时间：2018-09-01 08:36

【摘要】：本研究基于2009~2015年我国北京、河北、湖南、山东、山西、陕西六个地区脑炎脑膜炎症候群监测数据,针对腮腺炎病毒引起的脑炎脑膜炎(简称腮腺炎脑炎脑膜炎)病例检出情况和流行病学特征进行系统分析。结果显示,2009~2015年期间,我国六个监测地区腮腺炎病毒是引起病毒性脑炎脑膜炎的主要病原之一。在6 002例脑炎脑膜炎监测病例中,共检测到489例腮腺炎脑炎脑膜炎病例,腮腺炎病毒阳性检出率为8.15%。通过流行病学分析,发现腮腺炎脑炎脑膜炎和普通腮腺炎的流行病学特征是一致的。腮腺炎脑炎脑膜炎发病主要集中在冬春季节;15岁以下的儿童和青少年是腮腺炎脑炎脑膜炎的主要发病人群,占腮腺炎脑炎脑膜炎总病例数的89.16%,腮腺炎病毒检测的阳性病例数和阳性检出率男性高于女性;发病人群主要为散居儿童、学生和幼托儿童;腮腺炎脑炎脑膜炎临床表现主要症状以发热、恶心、呕吐和精神萎靡为主。部分患者还表现为嗜睡、抽搐、意识障碍、脑膜刺激征、颈项强直等中枢神经感染症状。15岁以下儿童和青少年是我国预防腮腺炎脑炎脑膜炎的重点人群,也是腮腺炎病毒减毒活疫苗免疫接种的重点人群。本文通过对2009~2015年脑炎脑膜炎症候群监测病例中腮腺炎脑炎脑膜炎病例进行分析,初步阐明了腮腺炎病毒在我国病毒性脑炎脑膜炎症候群中检出情况和流行特征,为我国腮腺炎的防控,尤其是腮腺炎病毒引起的脑炎脑膜炎的防控提供了一定的基础数据。
[Abstract]:This study was based on surveillance data of encephalitis meningitis syndrome in Beijing, Hebei, Hunan, Shandong, Shanxi and Shaanxi from 2009 to 2015 in China. The detection and epidemiological characteristics of mumps virus induced encephalitis meningitis (mumps meningitis) were systematically analyzed. The results showed that mumps virus was one of the main pathogens of viral encephalitis meningitis in six surveillance areas in China from 2009 to 2015. A total of 489 cases of mumps meningitis were detected in 6 002 cases of meningoencephalitis. The positive rate of mumps virus was 8.15%. The epidemiological characteristics of mumps meningitis and parotitis were consistent with those of common mumps. The incidence of mumps meningitis is mainly concentrated in children and adolescents under 15 years of age in winter and spring seasons. The positive cases and positive rate of mumps virus were higher in males than in females, and the incidence was mainly among scattered children, students and young children, and the incidence of mumps meningitis accounted for 89.16% of the total cases of mumps meningitis, and the positive rate of mumps virus was higher in males than in females. The main symptoms of mumps meningitis are fever, nausea, vomiting and mental retardation. Some of the patients also showed symptoms of central nervous infection, such as lethargy, convulsions, disturbance of consciousness, meningeal irritation, cervical rigidity and other symptoms of central nervous infection. Children and adolescents under the age of 15 were the key groups in preventing mumps meningitis in China. Is also the mumps virus attenuated live vaccine immunization key population. Based on the analysis of mumps meningitis cases from 2009 to 2015, the detection and epidemic characteristics of mumps virus in viral encephalitis meningitis syndrome in China were preliminarily explained. It provides some basic data for the prevention and control of mumps, especially the encephalitis and meningitis caused by mumps virus.
【作者单位】：中国疾病预防控制中心病毒病预防控制所卫生部医学病毒学和病毒病重点实验室世界卫生组织西太平洋区麻疹和风疹参比实验室;湖南省疾病预防控制中心;山东省疾病预防控制中心;首都医科大学附属北京儿童医院;河北省疾病预防控制中心;山西省疾病预防控制中心;陕西省疾病预防控制中心;安徽理工大学;北华大学附属医院;
【基金】：十一五国家科技重大专项(项目号:2009ZXI0004-202),题目:病毒性传染病病原谱流行规律及变异研究;项目号:2009ZXI0004-201),题目:自然疫源性传染病病原谱流行规律及变异研究) 十二五国家科技重大专项(项目号:2013ZXI0004-202);题目:病毒性传染病病原谱流行规律及变异研究;(项目号:2012ZXI0004-201);题目:自然疫源性传染病病原谱流行规律及变异研究~~
【分类号】：R373

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