程序性细胞死亡Pyroptosis最新研究进展

发布时间：2018-09-11 13:42

【摘要】：Pyroptosis是最近发现的一种依赖于半胱氨酸蛋白-1(Caspase-1)的程序性细胞死亡方式。这种死亡方式和细胞凋亡及其它程序性死亡在细胞学形态、分子机制上有着本质的区别。其主要特征为依赖于Caspase-1剪切激活和促炎症性细胞因子白介素(IL)-1β和IL-18的释放。而Caspase-1的活化受到胞内蛋白复合物炎症体的调控。该炎症体由NLRs蛋白(如NLRP3或NLRC4)、接头蛋白ASC以及Caspase-1构成。Pyroptosis最初是在伤寒沙门氏菌感染小鼠巨噬细胞的模型中被发现,随后研究显示Pyroptosis在细菌和病毒感染、自身免疫性疾病以及肿瘤发生中都起到关键性作用。对这种程序性死亡的深入研究将有助于对细菌感染防治和某些疾病的致病机制研究提供帮助,并最终为临床应用提供新思路。
[Abstract]:Pyroptosis is a recently discovered programmed cell death pattern dependent on cysteine protein 1 (Caspase-1). This mode of death is essentially different from apoptosis and other programmed cell death in cellular morphology and molecular mechanism. Its main characteristics are dependent on the activation of Caspase-1 shear and the release of interleukin (IL)-1 尾 and IL-18. The activation of Caspase-1 is regulated by the inflammatory body of intracellular protein complex. The inflammatory body consisted of NLRs proteins (such as NLRP3 or NLRC4), junction protein ASC, and Caspase-1. Pyroptosis was first found in a murine macrophage model infected with Salmonella typhimurium. Later studies showed that Pyroptosis was infected by bacteria and viruses. Autoimmune diseases and tumorigenesis play a key role. The further study of this kind of programmed death will be helpful to the prevention and treatment of bacterial infection and the study of pathogenetic mechanism of some diseases, and will finally provide a new idea for clinical application.
【作者单位】：江苏大学医学院病理教研室;江苏大学生命科学研究院;
【基金】：国家自然科学基金(编号:81502621、81502088) 江苏省自然科学基金(编号:BK20140539) 江苏大学高级人才科研启动基金项目((编号:14JDG065、15JDG021) 中国博士后科学基金(编号:2015M571677)
【分类号】：R363

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