脂肪酸β-氧化在淋巴管生成中的作用
发布时间：2018-09-13 07:06
【摘要】：正内壁覆盖着淋巴内皮细胞(lymphatic endothelial cells,LECs)的淋巴管对生命健康至关重要。但是代谢在淋巴管发育过程中的作用仍然尚未被阐明。Wong等发现,在LECs特异性缺失CPT1A(脂肪酸β-氧化的限速酶)的转基因小鼠中,淋巴管的发育被抑制。脂肪酸β-氧化可为LECs的增殖提供能量,并参与LECs分化过程中淋巴管标志物表达的表观遗传调节。其中
[Abstract]:Lymphatic vessels covering the inner wall of lymphatic endothelial cells (lymphatic endothelial cells,LECs) are vital to life and health. However, the role of metabolism in the development of lymphatic vessels has not been elucidated. Wong et al found that the development of lymphatic vessels was inhibited in transgenic mice with LECs specific CPT1A (fatty acid 尾 -oxidation rate-limiting enzyme). Fatty acid 尾 -oxidation can provide energy for the proliferation of LECs and participate in the epigenetic regulation of lymphatic markers expression during the differentiation of LECs. Of which
本文编号：2240429
[Abstract]:Lymphatic vessels covering the inner wall of lymphatic endothelial cells (lymphatic endothelial cells,LECs) are vital to life and health. However, the role of metabolism in the development of lymphatic vessels has not been elucidated. Wong et al found that the development of lymphatic vessels was inhibited in transgenic mice with LECs specific CPT1A (fatty acid 尾 -oxidation rate-limiting enzyme). Fatty acid 尾 -oxidation can provide energy for the proliferation of LECs and participate in the epigenetic regulation of lymphatic markers expression during the differentiation of LECs. Of which
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相关硕士学位论文 前1条
1 王淑梅;小鼠原始生殖细胞的分离鉴定及其迁移的表观遗传调节研究[D];内蒙古大学;2016年
，本文编号：2240429
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