高渗盐水对免疫细胞调节效应的研究进展

发布时间：2018-10-07 18:45

【摘要】：高渗盐水是指浓度高于9 g/L的氯化钠溶液,研究证实高渗盐水用于失血性休克及脑外伤患者的有效性主要在于其扩容作用及免疫调节效应。高渗盐水的免疫调节效应及其机制仍在探讨阶段,高渗盐水的免疫调节效应在颅脑损伤、脑出血和失血性休克等各种病理状态的改善中发挥着重要作用,主要是通过调节单核细胞、中性粒细胞等免疫细胞及免疫活性物质的分泌实现的。免疫调节的主要机制可能是高渗盐水影响免疫细胞表面分子的表达和某些活性物质的分泌。我们总结了高渗盐水的免疫调节效应及机制。
[Abstract]:Hypertonic saline is a sodium chloride solution with a concentration of more than 9 g / L. The effect of hypertonic saline on hemorrhagic shock and brain injury is mainly due to its capacity expansion and immune regulation effect. The immunomodulatory effect of hypertonic saline and its mechanism are still in the study stage. The immunomodulatory effect of hypertonic saline plays an important role in the improvement of various pathological conditions such as craniocerebral injury, cerebral hemorrhage and hemorrhagic shock. It is mainly by regulating the secretion of immune cells such as monocytes, neutrophils and immunoreactive substances. The main mechanism of immunomodulation may be that hypertonic saline affects the expression of molecules on the surface of immune cells and the secretion of some active substances. We summarize the immunomodulatory effect and mechanism of hypertonic saline.
【作者单位】：河北医科大学第三医院麻醉科;
【基金】：国家自然科学基金(30972832) 河北省临床医学优秀人才培养和基础课题研究(361005)
【分类号】：R392

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