潜伏期膜蛋白1与疾病关系的研究进展
发布时间：2018-10-17 09:58
【摘要】：EB病毒(EBV)是一种普遍存在的致癌病毒,是高度相关的淋巴和上皮肿瘤的来源和发展,包括伯基特淋巴瘤和鼻咽癌(NPC)等,EBV基因几乎可以在所有细胞中。EBV感染通常与少数潜伏病毒功能的蛋白质表达,包括潜伏膜蛋白LMP1和LMP2A等和巴尔核抗原1(EBNA1)。LMP1是肿瘤坏死因子受体超家族的成员,被认为是EBV的主要致瘤蛋白。在EB病毒中通过2个C末端结构域编码基因蛋白LMP1信号来驱动细胞生长,存活和转化。LMP1蛋白目前是惟一已被证实的EB病毒的癌基因,LMP1的表达参与了肿瘤的发生与发展,是目前癌症方面研究的重点。
[Abstract]:EB virus (EBV) is a widespread carcinogenic virus, which is the source and development of highly correlated lymphoid and epithelial tumors. Including Birkit's lymphoma and nasopharyngeal carcinoma (NPC) (NPC), the EBV gene can be expressed in almost all cells. EBV infection is usually associated with a small number of latent virus function proteins. LMP1 is a member of the tumor necrosis factor receptor superfamily and is considered to be the major tumor-causing protein of EBV. Cell growth, survival and transformation are driven by two C-terminal domain encoded gene protein LMP1 signals in EB virus. LMP1 protein is the only oncogene of EB virus that has been confirmed, and the expression of LMP1 is involved in the occurrence and development of tumor. Is the focus of current cancer research.
【作者单位】： 北京工业大学生命科学与生物工程学院肿瘤研究所;
【基金】：中国博士后科学基金(2014M560868) 北京市博士后科研活动经费(2015ZZ-01) 15级研究生培养-研究生教育-生命科学创新型研究生培养(学院)(015000541115008) 国家自然科技基金(81170875,81371052)
【分类号】：R373
本文编号：2276299
[Abstract]:EB virus (EBV) is a widespread carcinogenic virus, which is the source and development of highly correlated lymphoid and epithelial tumors. Including Birkit's lymphoma and nasopharyngeal carcinoma (NPC) (NPC), the EBV gene can be expressed in almost all cells. EBV infection is usually associated with a small number of latent virus function proteins. LMP1 is a member of the tumor necrosis factor receptor superfamily and is considered to be the major tumor-causing protein of EBV. Cell growth, survival and transformation are driven by two C-terminal domain encoded gene protein LMP1 signals in EB virus. LMP1 protein is the only oncogene of EB virus that has been confirmed, and the expression of LMP1 is involved in the occurrence and development of tumor. Is the focus of current cancer research.
【作者单位】： 北京工业大学生命科学与生物工程学院肿瘤研究所;
【基金】：中国博士后科学基金(2014M560868) 北京市博士后科研活动经费(2015ZZ-01) 15级研究生培养-研究生教育-生命科学创新型研究生培养(学院)(015000541115008) 国家自然科技基金(81170875,81371052)
【分类号】：R373
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