蜂王浆酶解产物对D-半乳糖模型小鼠体内抗衰老的作用

发布时间：2018-10-17 12:04

【摘要】：通过构建D-半乳糖诱导的衰老小鼠模型,检测蜂王浆酶解产物对衰老模型小鼠外部衰老表征和内部衰老表征的改善作用,全面衡量蜂王浆酶解产物的体内抗衰老活性。结果表明,在改善外部衰老方面,低剂量的蜂王浆酶解产物能够干预D-半乳糖诱导的小鼠体质量下降的状况。高、低剂量的蜂王浆酶解产物均能改善衰老小鼠活动能力下降的情况。同时,蜂王浆酶解产物还能够提高小鼠非空间性和空间性长期学习记忆能力,使之保持良好的记忆力,对空间和方位的快速判断力以及对学习和训练结果的巩固能力,具有优异的回避危害的学习能力及长期记忆能力。在改善内部衰老方面,蜂王浆酶解产物能延缓胸腺等器官的萎缩,表现出对器官衰老的抑制作用。蜂王浆酶解产物还能够提高小鼠血清超氧化物歧化酶、小鼠肝脏过氧化氢酶、小鼠肝脏谷胱甘肽过氧化物酶的活力并抑制小鼠脑中丙二醛的积累,高剂量效果等同或显著优于蜂王浆。
[Abstract]:By constructing an aging mouse model induced by D-galactose, the effects of royal jelly enzymatic hydrolysis products on the external and internal senescence characterization of aging model mice were examined, and the anti-aging activities of royal jelly enzymatic hydrolysis products in vivo were comprehensively evaluated. The results showed that low-dose royal jelly enzymatic hydrolysis could interfere with the decline of body mass induced by D-galactose. High and low doses of royal jelly enzymatic hydrolysis products can improve the decline of activity in aging mice. At the same time, the enzymatic hydrolysis products of royal jelly could also improve the ability of non-spatial and spatial long-term learning and memory in mice, so that they could maintain good memory, rapid judgment on space and orientation, and the ability to consolidate the results of learning and training. Excellent ability to avoid hazards and long-term memory. In the aspect of improving internal senescence, royal jelly enzymatic hydrolysis product can delay the atrophy of thymus and other organs, and show the inhibitory effect on organ senescence. The royal jelly hydrolysate could also increase the activity of serum superoxide dismutase (SOD), mouse liver catalase, mouse liver glutathione peroxidase (Glutathione peroxidase) and inhibit the accumulation of malondialdehyde (MDA) in mouse brain. The effect of high dose is equal or much better than that of royal jelly.
【作者单位】：浙江大学动物科学学院;
【基金】：国家蜂产业技术体系建设专项(NYCYTX-43) “十二五”国家科技支撑计划项目(2011BAD33B04)
【分类号】：R285.5;R-332

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