骨髓间充质干细胞的衰老特征及其与治疗的相关性

发布时间：2018-11-06 08:50

【摘要】：背景:骨髓间充质干细胞可能对年龄相关疾病敏感,是影响退行性疾病骨重建的重要因素之一。目的:综述骨髓间充质干细胞的衰老特征及治疗进展。方法:检索Pub Med数据库2006年6月至2016年6月关于骨髓间充质干细胞衰老及治疗的相关文章,以"MSCs,aging"为关键词进行检索,排除陈旧性和无关研究,最终选择关于骨髓间充质干细胞衰老及治疗的61篇文献,并参考《哈德兹老年医学》进行综述。结果与结论:骨髓来源间充质干细胞可支持免疫和造血系统中的造血祖细胞生长,促进骨髓组织修复,影响骨的生长和重建,其也会随着年龄及其他因素发生老化,进而影响其功能。衰老的骨髓间充质干细胞表现出端粒缩短、增殖和分化能力减弱、氧化应激水平增高等特点。目前研究可通过调节端粒酶活性,干预氧化应激或微环境中的Wnt/β-catenin等信号通路,应用p16、p53等基因表达或组蛋白乙酰转移酶、溶血磷脂酸等药物,以及通过机械力、能量限制等非药物手段来延缓或防止骨髓间充质干细胞的衰老,提高其临床疗效,但更确切的机制尚待进一步研究。
[Abstract]:Background: bone marrow mesenchymal stem cells may be sensitive to age-related diseases and may be one of the important factors affecting bone reconstruction in degenerative diseases. Objective: to review the aging characteristics and therapeutic progress of bone marrow mesenchymal stem cells (BMSCs). Methods: from June 2006 to June 2016, related articles on aging and treatment of bone marrow mesenchymal stem cells (BMSCs) were searched in Pub Med database. "MSCs,aging" was used as the key word to exclude the old and unrelated studies. Finally, 61 literatures on the aging and treatment of bone marrow mesenchymal stem cells were selected and reviewed with reference to Hadze Geriatrics. Results & conclusion: bone marrow-derived mesenchymal stem cells can support the growth of hematopoietic progenitor cells in the immune and hematopoietic system, promote bone marrow repair, and affect the growth and reconstruction of bone. And then affect its function. The aging bone marrow mesenchymal stem cells showed the characteristics of telomere shortening, decreased proliferation and differentiation, and increased oxidative stress. The present study can be done by regulating telomerase activity, interfering with signaling pathways such as Wnt/ 尾-catenin in oxidative stress or microenvironment, using p16 gene expression or histone acetyltransferase, lysophosphatidic acid and other drugs, as well as through mechanical force. Energy restriction and other non-drug methods can delay or prevent the aging of bone marrow mesenchymal stem cells (BMSCs) and improve its clinical efficacy. However, the more precise mechanism remains to be further studied.
【作者单位】：解放军成都军区昆明总医院细胞生物治疗中心干细胞与免疫细胞生物医药技术国家地方联合工程实验室云南省干细胞工程实验室昆明市干细胞与再生医学重点实验室;贵州医科大学;
【基金】：国家支持项目(2014BIO1B01) 昆明市重点项目(2015-1-S-00973)~~
【分类号】：R329.2

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