濒死呼吸对心脏骤停猪模型冠脉灌注压的影响
发布时间：2018-12-15 17:24
【摘要】：目的：观察心脏骤停(cardiac arrest, CA)家猪模型心室颤动(ventricular fibrillation, VF)后濒死呼吸的发生率、濒死呼吸频率分布及濒死呼吸对冠状动脉灌注压(coronary perfusion pressure, CPP)的影响。深入探讨濒死呼吸及其与CPP之间的关系和意义。 方法：健康家猪10头,雄性,体重(25.0±1.5)kg。常规麻醉、气管插管。经右股动脉置管至胸主动脉实时监测主动脉压力(AOP)。经右颈外静脉置管至右心房实时监测右心房压力(RAP)。经心内膜交流电刺激诱发VF致心脏骤停。未处理时间8分钟。采集单位时间内出现濒死呼吸动物数、濒死呼吸频率,采集濒死呼吸前后AOP、RAP,计算CPP。进行统计学分析。 结果：心脏骤停后所有动物均出现濒死呼吸。第1分钟,1只动物(10%),第2分钟,4只(40%),第3分钟7只(70%),第4-5分钟,所有动物(100%)均出现濒死呼吸,第6分钟7只(70%),第7分钟0只(0%)。濒死呼吸频率分布呈渐增-渐减模式。平均首次濒死呼吸出现时间为VF后2.02±0.84min。VF后第1分钟濒死呼吸频率0.2±0.6次/分；第2分钟1.2±1.7次/分；第3分钟2.7±2.4次/分；第4分钟3.7±1.6次/分；第5分钟VF后3.2±1.9次/分；第6分钟1.3±1.3次/分；第7分钟0.0±0.0次/分。平均末次呼吸出现时间为5.21±1.12min。濒死呼吸吸气前1秒CPP7.18±4.22mmHg；呼气后5秒8.75±4.38mmHg,与吸气前1秒比较p=0.02(p0.05)；呼气后6秒8.23±4.55mmHg,与吸气前1秒比较p=0.10(p0.05)。 结论：濒死呼吸是心脏骤停的伴随症状,高发于心脏骤停后4-5分钟,呈渐增-渐减模式。濒死呼吸后CPP升高,持续至呼气末5秒,有利于心肺复苏。
[Abstract]:Aim: to observe the incidence of near-death respiration after ventricular fibrillation (ventricular fibrillation, VF), the distribution of near-death respiration frequency and the effect of near-death respiration on coronary perfusion pressure (coronary perfusion pressure, CPP) after ventricular fibrillation (ventricular fibrillation, VF) in (cardiac arrest, CA) pig model of cardiac arrest. To explore the relationship and significance of near-death respiration and CPP. Methods: ten healthy domestic pigs, male, weight (25.0 卤1.5) kg. Routine anesthesia, tracheal intubation. Real-time Monitoring of Aortic pressure (AOP). Through right femoral artery Catheter to Thoracic aorta Real-time Monitoring of right Atrial pressure (RAP). Through right external jugular vein Catheter to right Atrial Cardiac arrest was induced by endocardial alternating current stimulation (VF). Unprocessed 8 minutes. The number of animals with near-death respiration and the rate of near-death respiration were collected in unit time. The CPP. was calculated by AOP,RAP, before and after the acquisition of near-death respiration. Statistical analysis was carried out. Results: all animals had near-death breathing after cardiac arrest. In the first minute, 1 animal (10%), 2 minutes, 4 (40%), 3 minutes 7 (70%), 4-5 minutes, all animals (100%) had near-death respiration, 7 animals (70%) at the sixth minute, 0 (0%) in the 7th minute. The distribution of near-death respiratory frequency was gradually increasing and decreasing. The mean onset time of first near-death respiration was 0.2 卤0.6 / min, 1.2 卤1.7 / min, 2.7 卤2.4 / min after 2. 02 卤0.84min.VF, 2. 2 卤1. 7, 2. 7 卤2. 4 / min after VF, 2. 2 卤1. 7, 2. 2 卤1. 7 / min after VF. 3. 7 卤1. 6 times / min, 3. 2 卤1. 9 times / min after VF at 5 min, 1. 3 卤1. 3 times / min at 6 min, 0. 0 卤0. 0 times / min at 7 min. The mean time of last respiration was 5.21 卤1.12 min. CPP7.18 卤4.22mmHg before inspiratory, 5.75 卤4.38mmHg after exhale, p0.02vs 1 second before inspiratory, 8.23 卤4.55mmHgafter exhalation, and 0.10 (p0.05) compared with 1 second before inhale. Conclusion: Near-death respiration is a concomitant symptom of cardiac arrest, which occurs 4-5 minutes after cardiac arrest in a gradual increasing-decreasing pattern. CPP increased after near-death respiration and lasted until the end of expiratory for 5 seconds, which was beneficial to cardiopulmonary resuscitation.
【学位授予单位】：遵义医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R-332
本文编号：2381023
[Abstract]:Aim: to observe the incidence of near-death respiration after ventricular fibrillation (ventricular fibrillation, VF), the distribution of near-death respiration frequency and the effect of near-death respiration on coronary perfusion pressure (coronary perfusion pressure, CPP) after ventricular fibrillation (ventricular fibrillation, VF) in (cardiac arrest, CA) pig model of cardiac arrest. To explore the relationship and significance of near-death respiration and CPP. Methods: ten healthy domestic pigs, male, weight (25.0 卤1.5) kg. Routine anesthesia, tracheal intubation. Real-time Monitoring of Aortic pressure (AOP). Through right femoral artery Catheter to Thoracic aorta Real-time Monitoring of right Atrial pressure (RAP). Through right external jugular vein Catheter to right Atrial Cardiac arrest was induced by endocardial alternating current stimulation (VF). Unprocessed 8 minutes. The number of animals with near-death respiration and the rate of near-death respiration were collected in unit time. The CPP. was calculated by AOP,RAP, before and after the acquisition of near-death respiration. Statistical analysis was carried out. Results: all animals had near-death breathing after cardiac arrest. In the first minute, 1 animal (10%), 2 minutes, 4 (40%), 3 minutes 7 (70%), 4-5 minutes, all animals (100%) had near-death respiration, 7 animals (70%) at the sixth minute, 0 (0%) in the 7th minute. The distribution of near-death respiratory frequency was gradually increasing and decreasing. The mean onset time of first near-death respiration was 0.2 卤0.6 / min, 1.2 卤1.7 / min, 2.7 卤2.4 / min after 2. 02 卤0.84min.VF, 2. 2 卤1. 7, 2. 7 卤2. 4 / min after VF, 2. 2 卤1. 7, 2. 2 卤1. 7 / min after VF. 3. 7 卤1. 6 times / min, 3. 2 卤1. 9 times / min after VF at 5 min, 1. 3 卤1. 3 times / min at 6 min, 0. 0 卤0. 0 times / min at 7 min. The mean time of last respiration was 5.21 卤1.12 min. CPP7.18 卤4.22mmHg before inspiratory, 5.75 卤4.38mmHg after exhale, p0.02vs 1 second before inspiratory, 8.23 卤4.55mmHgafter exhalation, and 0.10 (p0.05) compared with 1 second before inhale. Conclusion: Near-death respiration is a concomitant symptom of cardiac arrest, which occurs 4-5 minutes after cardiac arrest in a gradual increasing-decreasing pattern. CPP increased after near-death respiration and lasted until the end of expiratory for 5 seconds, which was beneficial to cardiopulmonary resuscitation.
【学位授予单位】：遵义医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R-332
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