睡眠剥夺对健康成人学习记忆网络影响的功能磁共振研究

发布时间：2018-12-15 17:10

【摘要】：目的探讨36 h完全睡眠剥夺对健康受试学习记忆网络的影响。方法利用血氧水平依赖功能磁共振成像技术分别采集18例健康成年男性正常睡眠状态及36 h完全睡眠剥夺后静息态功能磁共振数据,利用REST软件自动化解剖标记模板,选取双侧海马为种子点做功能连接,再以SPM 8软件进行配对t检验,比较睡眠剥夺前后双侧海马与全脑功能连接的变化。最后将功能连接显著的脑区与韦氏记忆量表的记忆商差值(睡眠剥夺后减去正常睡眠状态)做相关分析。结果与睡眠剥夺前对比,36 h睡眠剥夺后:双侧海马种子点主要与右侧后扣带回皮质呈显著正功能连接;与双侧中央后回呈显著负功能连接。与睡眠剥夺前相比,韦氏记忆量表的记忆商显著降低,功能连接与韦氏记忆量表的记忆商差值相关分析显示:双侧海马种子点与右侧后扣带回皮质间功能连接与韦氏记忆量表的记忆商差值之间呈负相关性(左侧:r=-0.463,P=0.015;右侧:r=-0.546,P=0.003)。结论与正常睡眠状态相比,睡眠剥夺对双侧海马功能连接存在显著影响,主要表现为与右侧扣带回皮质间功能连接显著上升,而与双侧中央后回间功能连接显著下降。其中前者可能是睡眠剥夺后学习记忆能力调控方面的重要神经机制。
[Abstract]:Objective to investigate the effect of 36 h complete sleep deprivation on learning and memory network in healthy subjects. Methods functional magnetic resonance imaging (fMRI) was used to collect 18 healthy adult men's normal sleep state and 36 h rest state after complete sleep deprivation. REST software was used to automate anatomic marker template. The bilateral hippocampus was selected as the seed point for functional connection, and then paired t test with SPM 8 software was used to compare the changes of bilateral hippocampal and global brain functional connections before and after sleep deprivation. Finally, the difference of memory quotient of Wechsler memory scale (subtract normal sleep state after sleep deprivation) was analyzed. Results compared with those before sleep deprivation, after 36 h sleep deprivation, the bilateral hippocampal seed points were significantly positively connected with the right posterior cingulate cortex and negatively connected with the bilateral postcentral gyrus. The memory quotient of Wechsler memory scale was significantly lower than that before sleep deprivation. The correlation analysis between the functional connection and the memory quotient difference of Wechsler memory scale showed that there was a negative correlation between the bilateral hippocampal seed points and the right posterior cingulate cortex and the memory quotient difference of the Wechsler memory scale (left: r-0.463. P0. 015; Right side: r-0.546P0. 003). Conclusion compared with normal sleep state, sleep deprivation has a significant effect on bilateral hippocampal functional junction, mainly in the right cingulate cortex increased significantly, but with bilateral central posterior gyrus functional connection decreased significantly. [WT5HZ] [WT5 "BZ] [WT5" BZ] The former may play an important role in the regulation of learning and memory after sleep deprivation.
【作者单位】：安徽医科大学;中国人民解放军空军总医院CT&MRI科;中国人民解放军空军总医院心理科;
【基金】：北京市自然科学基金面上项目(编号:7152145)
【分类号】：R338

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