冠状动脉微循环功能障碍动物模型及中医药防治研究进展

发布时间：2019-01-11 07:40

【摘要】：冠状动脉微循环功能障碍(CMD)是心脏X综合征、经皮冠状动脉介入治疗(PCI)后无复流等微循环病变的共同发病机制。随着现代影像学的迅速发展,CMD的发生和防治得到越来越多的关注。CMD动物模型是研究疾病发病机制及评价药物作用的必不可少的工具,选择合适的CMD动物模型建立方法是开展CMD实验研究首先面临的问题。临床及实验研究显示,中医药在CMD的防治方面具有一定的特色。如何进一步阐明中药作用机制寻求最佳的中西医结合治疗方案,将是中医药干预CMD的研究重点。该文将从冠状动脉微循环障碍动物模型的建立评价方法及中医药防治冠状动脉微血管环障碍的研究进展进行综述,旨为冠状动脉微循环障碍实验及中医药的实验研究提供参考。
[Abstract]:Coronary microcirculation dysfunction (CMD) is a common pathogenesis of cardiac X syndrome and no reflow after percutaneous coronary intervention. With the rapid development of modern imaging, more and more attention has been paid to the occurrence and prevention of CMD. CMD animal model is an indispensable tool to study the pathogenesis of disease and evaluate the role of drugs. It is the first problem to choose suitable CMD animal model establishment method to carry out the CMD experiment research. Clinical and experimental studies show that Chinese medicine has certain characteristics in the prevention and treatment of CMD. How to further elucidate the mechanism of traditional Chinese medicine and seek the best combination of traditional Chinese and Western medicine treatment plan will be the focus of Chinese medicine intervention in CMD. This article reviews the establishment and evaluation of animal model of coronary microcirculation disorder and the progress of Chinese medicine in the prevention and treatment of coronary microvascular loop disorder, in order to provide a reference for the experimental study of coronary microcirculation disorder and traditional Chinese medicine.
【作者单位】：中国中医科学院西苑医院基础医学研究所;中药药理北京市重点实验室;
【基金】：国家重点基础研究发展计划(973)项目(2015CB554405)
【分类号】：R259;R-332

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