栀子苷对糖尿病模型大鼠认知功能障碍的改善作用研究

发布时间：2019-02-22 14:00

【摘要】：目的:研究栀子苷对糖尿病模型大鼠认知功能障碍的改善作用。方法:将50只大鼠随机分为空白对照组(蒸馏水)、模型组(蒸馏水)和栀子苷低、中、高剂量组(5、10、20 g/kg),每组10只。除空白对照组外,其余4组大鼠均饲以高糖高脂饲料+注射链脲佐菌素复制糖尿病模型。成模后,各组大鼠ig相应药物,每日1次,连续8周。末次给药后检测各组大鼠空腹血糖(FPG)、糖化血红蛋白(HbA_1c)水平,并检测Morris水迷宫实验的逃避潜伏期和Y迷宫实验的行为正确率。结果:与空白对照组比较,模型组大鼠FPG、HbA_1c水平明显升高,逃避潜伏期明显延长,Y迷宫行为正确率明显降低,差异均有统计学意义(P0.05)。与模型组比较,栀子苷各剂量组大鼠上述指标均明显改善(P0.05),且与剂量呈正相关(P0.05)。结论:栀子苷可有效降低糖尿病模型大鼠血糖水平,改善其认知功能障碍。
[Abstract]:Objective: to study the effect of geniposide on cognitive dysfunction in diabetic rats. Methods: 50 rats were randomly divided into control group (distilled water), model group (distilled water) and low, middle and high dose groups (5,10,20 g/kg) with 10 rats in each group. Except the blank control group, the other 4 groups were fed with streptozotocin (streptozotocin) injection with high sugar and high fat diet to establish diabetic model. The rats in each group were treated with ig once a day for 8 weeks. The fasting blood glucose (FPG), glycosylated hemoglobin (HbA_1c) levels were measured after the last administration. The escape latency of Morris water maze test and the correct behavior rate of Y maze test were measured. Results: compared with the blank control group, the level of FPG,HbA_1c in the model group was significantly increased, the escape latency was prolonged, and the correct rate of Y maze behavior was significantly decreased (P0.05). Compared with the model group, the above indexes were significantly improved in each dosage group of geniposide (P0.05), and positively correlated with the dose (P0.05). Conclusion: geniposide can effectively reduce the level of blood glucose and improve the cognitive function of diabetic rats.
【作者单位】：江西科技学院护理学院;
【基金】：江西省教育厅科学技术研究课题(No.GJJ161137) 江西科技学院自然科学研究项目(No.16ZRYB03)
【分类号】：R285.5;R-332

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