异常修饰后高密度脂蛋白组分的改变对其功能的影响

发布时间：2019-03-04 10:23

【摘要】：高密度脂蛋白(high-density lipoprotein,HDL)是由载脂蛋白、脂质和多种功能蛋白所组成的结构复杂的多功能复合物。正常人血浆中的HDL主要通过胆固醇逆向转运(reverse cholesterol transport,RCT)发挥抗动脉粥样硬化(atherosclerosis,AS)作用,除此之外,HDL还有修复内皮细胞、抗炎、抗氧化和抗凋亡等作用。在全身炎症或代谢性疾病中,HDL组分被异常修饰,使其成分和功能发生改变,进而转变为功能失调HDL。功能失调HDL在成分和功能上均发生了改变:成分上载脂蛋白A-Ⅰ(apolipoprotein A-Ⅰ,apo A-Ⅰ)、对氧磷酶(paraoxonase,PON)和血小板活化因子乙酰水解酶(platelet activating factor acetylhydrolase,PAF-AH)等减少,而血清淀粉样蛋白A(serum amyloid A,SAA)、甘油三酯(triglyceride,TG)和氧化脂质等增加;功能上不仅失去了抗AS、抗炎、抗氧化等作用,反而具有促炎作用,可见盲目升高血浆HDL-C的含量并不一定能达到预期效果。因此了解异常修饰后HDL成分和功能的改变对深入了解功能失调HDL的致病机制具有重要的指导意义。
[Abstract]:High-density lipoprotein (HDL) is a complex complex composed of apolipoprotein, lipid and various functional proteins. HDL in normal human plasma plays an important role in anti-atherosclerosis (AS) by reverse cholesterol transport (RCT). In addition, HDL also has the effects of repairing endothelial cells, anti-inflammatory, anti-oxidation and anti-apoptosis. In the whole body inflammation or metabolic disease, the HDL component is abnormally modified to change the composition and function of the HDL component, and then the HDL component is converted into a functional disorder HDL. The functional disorder HDL has changed in the composition and function: the apolipoprotein A-I (apo A-I, apo A-I) in the component, the paraoxonase (PON) and the platelet activating factor B-hydrolase (PAF-AH), etc., and the serum amyloid A (SAA), Triglyceride (TG) and oxidized lipid increase; the function not only has the effects of anti-AS, anti-inflammatory, anti-oxidation and the like, but also has the effect of promoting the inflammation, and the content of the high-blood plasma HDL-C is not always expected to reach the expected effect. Therefore, it is of great significance to understand that the change of HDL composition and function after the abnormal modification is of great significance for the in-depth understanding of the pathogenesis of functional disorder HDL.
【作者单位】：泰山医学院动脉粥样硬化研究所山东省高校动脉粥样硬化重点实验室;泰山医学院基础医学院;
【基金】：supported by the National Natural Science Foundation of China (No.81670422 and 81200216) the Young Taishan Scholars Program of Shandong Province, China (No.tsqn20161045) the Science and Technology Development Program of Shandong Province (No.2014GSF118081) the National Undergraduate Training Programs for Innovation and Entrepreneurship of China (No.201510439117)
【分类号】：R3411

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