流脑多糖疫苗和流脑结合疫苗的安全性观察

发布时间：2019-03-30 23:54

【摘要】：目的比较流脑多糖疫苗和流脑结合疫苗的安全性。方法选择6~18月龄和36~38月龄的常住健康人群,分别随机分为多糖疫苗组和结合疫苗组接种相应疫苗。6~18月龄儿童间隔3个月接种同种疫苗第2剂,接种后进行30 min即时反应和72 h反应的随访观察。结果不论1剂或2剂接种,A群流脑多糖疫苗、A+C群流脑多糖疫苗和A+C群流脑结合疫苗均表现出良好的耐受性;总体不良反应发生率为3.44%,均为轻度。各组间差异无统计学意义(χ2=0.80,P=0.67;χ2=0.79,P=0.67;χ2=3.13,P=0.21)。结论流脑多糖疫苗和流脑结合疫苗在儿童中均表现出良好的安全性,建议将流脑结合疫苗纳入国家免疫规划,提高预防效果并扩大菌群覆盖范围。
[Abstract]:Objective to compare the safety of cerebrospinal polysaccharide vaccine and cerebrospinal meningitis combined vaccine. Methods healthy people aged 6-18 months and 36-38 months old were randomly divided into two groups: the vaccine group and the combined vaccine group. The second dose of the same vaccine was given to the children aged 6 months and 18 months at an interval of 3 months, and the children aged 6 months and 18 months were randomly divided into two groups: the polysaccharide vaccine group and the combined vaccine group. All patients were followed up for 30 min immediate response and 72 h response. Results both group A cerebrospinal polysaccharide vaccine (, A C) and group A / C combined vaccine showed good tolerance, and the overall adverse reaction rate was 3.44%, all of which were mild. There was no significant difference among the three groups (蠂 2 = 0.80, P = 0.67; 蠂 2 = 0.79, P = 0.67; 蠂 2 = 3.13, P = 0.21). Conclusion both cerebrospinal polysaccharide vaccine and cerebrospinal fluid combined vaccine are safe in children. It is suggested that the vaccine should be incorporated into the national immunization program to improve the preventive effect and expand the coverage of the flora.
【作者单位】：南昌市疾病预防控制中心;
【分类号】：R392-33

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