病毒与宿主细胞的糖基化修饰及相关功能

发布时间：2019-04-09 12:41

【摘要】：病毒的复制和对宿主的入侵与自身结构蛋白的糖基化修饰密切相关.对于宿主而言,在病毒感染宿主和宿主抗病毒的过程中,宿主的糖基化过程一方面可抑制病毒的复制和入侵,另一方面可促进病毒对宿主的感染,抑制宿主糖苷酶可抑制病毒的复制.从病毒方面来看,由于病毒自身缺乏糖基化修饰系统,病毒的糖基化过程是借宿主细胞内的合成系统对自身进行糖基化修饰.病毒的糖基化过程对病毒蛋白的折叠与稳定、病毒的感染和入侵、参与识别宿主细胞受体和参与病毒的免疫逃逸等过程起着重要的作用.随着糖基化研究技术的发展,以糖基化为基础的功能应用也越来越深入:如新型病毒疫苗和新型抗病毒药物的研制,以糖蛋白质组学研究为基础的质谱技术和生物信息学方法的发展,以及利用糖基化对病毒性疾病的诊断和治疗等,这些均为糖基化深入研究发展奠定了基础.本文就病毒与宿主细胞糖基化过程、相关功能以及研究应用等进展作一综述.
[Abstract]:Viral replication and host invasion are closely related to glycosylation of their structural proteins. As far as the host is concerned, in the course of virus infection and anti-virus, the glycosylation process of the host can inhibit the replication and invasion of the virus on the one hand, and promote the infection of the virus to the host on the other. Inhibition of host glycosidase can inhibit virus replication. From the aspect of virus, because of the lack of glycosylation modification system, the glycosylation process of the virus is to modify itself through the synthesis system of host cells. The glycosylation of virus plays an important role in the folding and stabilization of viral protein, infection and invasion of virus, recognition of host cell receptor and immune escape of virus. With the development of glycosylation technology, glycosylation-based functional applications have become more and more in-depth: for example, the development of new viral vaccines and new antiviral drugs, The development of mass spectrometry and bioinformatics methods based on glycosylation, as well as the diagnosis and treatment of viral diseases by glycosylation, have laid the foundation for further research and development of glycosylation. In this paper, the progress of glycosylation between virus and host cells, related functions and research applications were reviewed.
【作者单位】：武汉大学病毒学国家重点实验室湖北省过敏及免疫相关疾病重点实验室武汉大学医学研究院武汉大学基础医学院免疫学系;
【基金】：国家自然科学基金资助项目(21572173,31370197)~~
【分类号】：R373

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