脂肪因子Apelin的生物学功能及调节机制
发布时间：2019-06-22 17:47
【摘要】：Apelin是G蛋白偶联的受体血管紧张素Ⅱ受体样蛋白-J(APJ)的天然配体。过去的研究表明,Apelin在心血管系统、神经系统及免疫系统等方面发挥重要的作用,包括调控中枢神经信号传导、诱导血管生成、参与免疫应答的调节等。近年来Apelin被确定为一种新型的脂肪细胞因子,可增加整体能量的消耗、提高胰岛素的敏感性从而抑制胰岛素抵抗的发生,与肥胖及其相关疾病胰岛素抵抗有重要关联。目前关于Apelin调控机制的研究有抑制脂肪生成和抑制脂肪分解两种不同的报道,有待于进一步探讨研究。现就Apelin的结构、生理功能及其对脂肪代谢的调控机制进行简要综述,并对今后在研究和应用方面做了展望。
[Abstract]:Apelin is a natural ligand of G protein-coupled receptor angiotensin II receptor-like protein-J (APJ). Previous studies have shown that Apelin plays an important role in cardiovascular system, nervous system and immune system, including regulating signal transduction of central nervous system, inducing angiogenesis, participating in the regulation of immune response and so on. In recent years, Apelin has been identified as a new type of adipocytokines, which can increase the overall energy consumption, improve insulin sensitivity and inhibit the occurrence of insulin resistance, which is closely related to obesity and its related diseases. At present, there are two different reports on the regulation mechanism of Apelin, which are inhibition of fat production and inhibition of fat decomposition, which need to be further studied. In this paper, the structure, physiological function and regulation mechanism of Apelin on fat metabolism are briefly reviewed, and the research and application in the future are prospected.
【作者单位】： 山西师范大学生命科学学院;
【基金】：国家自然科学基金项目(30972091)
【分类号】：R3411
[Abstract]:Apelin is a natural ligand of G protein-coupled receptor angiotensin II receptor-like protein-J (APJ). Previous studies have shown that Apelin plays an important role in cardiovascular system, nervous system and immune system, including regulating signal transduction of central nervous system, inducing angiogenesis, participating in the regulation of immune response and so on. In recent years, Apelin has been identified as a new type of adipocytokines, which can increase the overall energy consumption, improve insulin sensitivity and inhibit the occurrence of insulin resistance, which is closely related to obesity and its related diseases. At present, there are two different reports on the regulation mechanism of Apelin, which are inhibition of fat production and inhibition of fat decomposition, which need to be further studied. In this paper, the structure, physiological function and regulation mechanism of Apelin on fat metabolism are briefly reviewed, and the research and application in the future are prospected.
【作者单位】： 山西师范大学生命科学学院;
【基金】：国家自然科学基金项目(30972091)
【分类号】：R3411
【共引文献】
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1 张宝乐;猪Gpr3基因特征、表达及其对卵泡颗粒细胞的影响[D];南京农业大学;2012年
2 杨燕燕;Ghrelin对绵羊早期胚胎发育影响的研究[D];内蒙古农业大学;2014年
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