低氧诱导因子-1α和反义低氧诱导因子-1α的研究进展

发布时间：2019-07-01 09:33

【摘要】：低氧诱导因子(HIF)-1α是细胞感受氧体积分数高低并作出生物反应的关键性分子,具有促进血管生成、调节p H、诱导自吞噬和程序性细胞死亡以及促进间质干细胞自我更新及分化作用。HIF-1α还参与正畸牙移动及牙周炎过程中牙周组织的修复与改建,促使细胞适应低氧环境,完成牙槽骨成骨与吸收过程。反义低氧诱导因子(a HIF)-1α是一种自然反义转录因子,对HIF-1α具有反义调控作用;而HIF-1α对a HIF-1α亦可能存在反馈调节机制。HIF-1α表达于大多数常见的癌组织及其转移灶中,是肿瘤的一个标志性因子,越来越多的研究将其作为治疗各类肿瘤的靶点。研究并明确HIF-1α与a HIF-1α的作用及其精确的调控机制,可为寻找治疗各种疾病的靶点和调控生理过程提供新的契机。
[Abstract]:The hypoxia-inducible factor (HIF) -1 is the key molecule of the cell's oxygen volume fraction and makes a biological response, which has the effects of promoting angiogenesis, regulating the p H, inducing autophagy and programmed cell death, and promoting the self-renewal and differentiation of the mesenchymal stem cells. HIF-1 is also involved in the repair and alteration of the periodontal tissues during the process of orthodontic tooth movement and periodontitis, which can promote the cell to adapt to the low-oxygen environment and complete the bone formation and absorption process of the alveolar bone. The anti-sense hypoxia-inducible factor (a HIF) -1 is a natural antisense transcription factor, and has an anti-sense regulation effect on the HIF-1 antigen; and the HIF-1 antigen may also have a feedback regulation mechanism for a HIF-1. The HIF-1 gene is expressed in most common cancer tissues and their metastases, is a symbol of the tumor, and more and more research will be used as a target for treating various tumors. The effect of HIF-1 and a HIF-1 and its precise control mechanism can be studied and a new opportunity for finding a target for treating various diseases and regulating physiological process can be provided.
【作者单位】：中山大学光华口腔医学院·附属口腔医院正畸科;广东省口腔医学重点实验室;
【基金】：广东省自然科学基金(2015A030313083)~~
【分类号】：R363

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