次声对雄性大鼠生殖系统的影响及药物防护研究

发布时间：2018-01-02 02:16

本文关键词：次声对雄性大鼠生殖系统的影响及药物防护研究　出处：《第四军医大学》2006年博士论文　论文类型：学位论文

【摘要】：次声波是频率为0.0001Hz-20Hz的声波，具有传播衰减小、传播距离远、易于衍射、一般听不到、达到一定参数可引发共振等特点。次声在现代生活中较普遍存在，自然次声源，，如：地震、大风、瀑布、火山：交通运输性次声源，如：卡车、飞机、船舶、火车、地铁列车等运行；工业性次声源，如：重型机械、空气压缩机、加热和冷却设备；家用电器，如：洗衣机、空调某些军事活动也伴有次声的产生，如：战机、坦克、装甲车等运行，火箭发射等，因此，次声已成为环境噪声污染的重要组成部分；此外，当今一些军事技术发达国家，如美国、俄罗斯、英国等，已研制成非致死性次声武器。基于上述情况，在国际上关于次声的生物学效应日益受到关注。有关次声对生殖系统的作用效应无疑是需要重视并认真研究的问题，但有关这方面的研究报道在国内外尚少见。本研究将通过动物实验观察8Hz、90dB／130dB次声对雄性生殖系统的影响，以为次声防护提供依据。目的：系统观察8Hz、90dB／130dB次声对雄性大鼠生殖行为、生育能力、性激素水平的影响及自然恢复规律；探讨部分相关机制；观察不同剂量的美满霉素对次声性睾丸损伤的防护效果。方法：将性成熟雄性SD大鼠进行8Hz、90dB或130dB次声暴露1、7、14、21d(2h／d)，于次声作用终止后1、7、14d观察大鼠性行为(爬背潜伏期、爬背次数、射精潜伏期、射精次数)；取附睾检测生精能力(精子计数、畸形率和活动率)；取睾丸组织进行组织细胞学和超微结构观察；检测睾丸组织
[Abstract]:The acoustic frequency is 0.0001Hz-20Hz wave propagation attenuation, with small, long transmission distance, easy diffraction, cannot hear, certain parameters can cause resonance characteristics. Infrasound is ubiquitous in modern life, such as: natural infrasound source, earthquake, wind, waterfalls, volcano: transportation of infrasound source. Such as trucks, aircraft, ship, train, subway train operation; numerous industrial sources, such as heavy machinery, air compressor, heating and cooling equipment; household appliances, such as washing machine, air conditioning is also accompanied by some of the military activities of infrasound generation, such as aircraft, tanks, armored vehicles and rocket launching operation so, therefore, has become an important part of infrasound environmental noise pollution; in addition, some of today's military technology in developed countries, such as the United States, Russia, Britain, has developed a non lethal infrasonic weapon. Based on the above, in international Shang Guan The biological effect of infrasound on more attention. The effect of infrasound on the reproductive system is the need to pay attention to and study the problem, but the research reports on this aspect is still rare at home and abroad. This study will observe the 8Hz through animal experiment, effect of 90dB / 130dB infrasound on the male reproductive system, which provide the basis for infrasound door.
Objective: To observe the effects of 8Hz, 90dB / 130dB infrasound on reproductive behavior, fertility, sex hormone levels and natural recovery in male rats, and explore some related mechanisms, and observe the protective effects of minocycline at different doses on infrasonic testicular injury.
Methods: adult male SD rats were 8Hz, 90dB or 130dB 1,7,14,21d infrasound exposure (2H / D), to infrasound after termination of 1,7,14d to observe the behavior of rats (climb back latency, climb back number, the latency of ejaculation, ejaculation frequency); detection of epididymal spermatogenic ability (sperm count, malformation rate and the activity rate); testicular tissue histopathology and ultrastructure of testis tissue was detected;

【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R363

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