抗CD137L抗体对小鼠sGVHD和aGVHD的抑制效应rhIL18对小鼠骨髓移植后aGVHD的抑制效应

发布时间：2018-01-04 13:13

本文关键词：抗CD137L抗体对小鼠sGVHD和aGVHD的抑制效应rhIL18对小鼠骨髓移植后aGVHD的抑制效应　出处：《山东大学》2006年博士论文　论文类型：学位论文

【摘要】：目的骨髓移植(bone marrow transplantation，BMT)是治疗白血病、恶性肿瘤、再生障碍性贫血以及免疫缺陷等疾病的重要手段。根据骨髓来源的不同，可以将骨髓移植分为自体骨髓移植(autologous BMT)、同基因骨髓移植(syngeneic BMT)、同种异体骨髓移植(allogeneic BMT)。由于自体骨髓移植骨髓来源于自身、同基因骨髓移植的骨髓来自基因型完全相同的个体，临床上一般无明显的排斥反应，移植的成功率高，但其缺点是移植后疾病的复发率高。同种异体骨髓移植的骨髓来自基因型不同的个体，移植后常出现严重的并发症-移植物抗宿主病(graft versus host disease，GVHD)，使骨髓移植失败，导致成功率降低，但其优点是一旦移植成功，疾病的复发率低。临床研究发现，同种异体BMT后发生GVHD的病人白血病复发率明显低于病情相似但未发生GVHD的患者，，动物实验进一步证明GVHD具有抗白血病作用(graft-versus-leukemia，GVL)，能降低白血病的复发。根据这些结果，人们推测自身或同基因型BMT受者白血病复发的主要原因之一可能是无GVL作用，因此，如果在自身或同基因型骨髓移植后能诱导适度的GVHD产生GVL将可预防白血病的复发，提高治疗效果。Glazier和Bryson等先后用环孢素A(CsA)短期治疗在同基因型骨髓移植的大鼠和小鼠人工诱导出GVHD样症状，称同基因型GVHD(syngeneic GVHD，SGVHD)，令人们感兴趣的是发现SGVHD同样具有抗白血病作用。目前，自身骨髓移植
[Abstract]:objective
Bone marrow transplantation (bone marrow transplantation, BMT) is the treatment of leukemia, malignant tumor, an important means of aplastic anemia and immunodeficient diseases. According to the different source of bone marrow, bone marrow transplantation can be divided into autologous bone marrow transplantation (autologous BMT), with the base for bone marrow transplantation (syngeneic BMT), allogeneic bone marrow transplantation (allogeneic BMT). The autologous bone marrow transplantation of bone marrow from their own, syngeneic bone marrow transplantation of bone marrow from genetically identical individuals, clinically no obvious rejection reaction, transplanted into high power, but its disadvantage is the disease with high recurrence rate after transplantation. Allogeneic bone marrow transplantation of bone marrow from different genotypes individuals often appear serious complications after transplantation and graft-versus-host disease (graft versus host disease, GVHD), the bone marrow transplant failure, resulting in lower success rate, but its advantage is a The relapse rate of the disease is low.
The clinical study found that the occurrence of GVHD after allogeneic BMT patients relapse rate was significantly lower than that in similar conditions but without GVHD patients, the animal experiments prove that GVHD has the effect of anti leukemia (graft-versus-leukemia, GVL), can reduce the recurrence of leukemia. According to these results, people speculate itself or the same genotype BMT by one of the main causes of recurrence leukemia may be no GVL effect, therefore, if can induce moderate GVHD GVL will prevent the relapse of leukemia after autologous bone marrow transplantation, improve the therapeutic effect of.Glazier and Bryson successively with cyclosporine A (CsA) artificial short-term treatment induce GVHD like symptoms in syngeneic bone marrow transplantation rats and mice, that same genotype GVHD (syngeneic GVHD SGVHD), who is interested in discovering SGVHD also has anti leukemia effect. At present, autologous bone marrow transplantation

【学位授予单位】：山东大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R392

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