NF-κB介导线粒体依赖的神经细胞凋亡途径

发布时间：2018-01-06 13:14

本文关键词：NF-κB介导线粒体依赖的神经细胞凋亡途径　出处：《癌变.畸变.突变》2014年01期 　论文类型：期刊论文

【摘要】：中枢神经系统损伤往往伴随着大量神经细胞凋亡,凋亡过程中许多重要环节的发生均与细胞内源性凋亡通路线粒体途径密切相关,由各种上游信号通路介导的线粒体凋亡机制是多年研究的热点。诸多信号通路中,其中具有多向转录调节作用的蛋白质核转录因子(NF-κB)的活化更引起人们的关注,其在神经细胞的增殖、转化、凋亡和死亡等多种生理和病理过程中起重要作用,但具体促凋亡的机制尚不明确。因此深入研究NF-κB通路与线粒体依赖的神经细胞凋亡途径之间的关系,将有助于开辟防治中枢神经系统损伤的新途径。本文就NF-κB介导线粒体依赖的神经细胞凋亡途径作一综述。
[Abstract]:The central nervous system injury is often accompanied by a large number of nerve cell apoptosis, many important links in the process of apoptosis are associated with the endogenous apoptosis pathway of mitochondrial pathway, mitochondrial apoptosis by various upstream signaling pathways mediated is a hot study for many years. Many signaling proteins, nuclear transcription factor which has multi function in transcription regulation (NF- K B) activation more attention, the neural cell proliferation, transformation, apoptosis and death plays an important role in many physiological and pathological processes, but the specific mechanism of promoting apoptosis is not clear. So the relationship between nerve cell apoptosis pathway research of NF- B pathway and mitochondria dependent that will help to open up a new way to prevent the damage of the central nervous system. In this paper, NF- kappa B mediated neuronal mitochondrial dependent apoptotic pathway is reviewed.

【作者单位】：浙江工业大学药学院;
【基金】：浙江省自然基金项目(LY13H090006) 全国临床医药研究专项基金(L2011079)
【分类号】：R346
【正文快照】： 脑出血、脑缺血等中枢神经系统疾病的发生发展过程中往时,由于水和溶质的侵入使基质肿胀,并导致外膜破裂,膜间[1]往伴随着各种病理性损伤,如炎症等,在脑组织炎症反应中隙的促凋亡因子,如细胞色素C(cytochrome C,Cyt C)和细胞凋[2][8]最常见的是小胶质细胞的活化增生和白细胞的

【共引文献】