腹腔内出血动物模型EIT监护实验研究

发布时间：2018-01-19 22:51

本文关键词： 腹腔内出血生物电阻抗图像监护动物模型　出处：《第四军医大学》2006年硕士论文　论文类型：学位论文

【摘要】：腹腔内出血多发生在腹部一些重要的脏器部位，如：肝脏、脾脏等。由于引发原因众多，如撞击、刺伤以及手术后出血。因而对其进行有效的诊断、监护困难较大。在国家自然基金重点课题“电阻抗图像监护技术基础研究”的资助下，基于EIT技术无创、动态成像并针对腹腔内出血敏感的特点，课题组对电阻抗监护腹腔内出血相关问题进行了一系列研究。课题组已开发出可应用于实验研究的腹部阻抗成像监护样机。此时，需要建立适合对腹部内出血进行EIT监护实验的恰当动物模型，并进行监护实验，以使后继续深入续研究。在此背景下，进行了如下一系列实验研究。 1)家兔腹腔内注血模型一维阻抗测量在前期测量腹腔内出血时腹部基础阻抗变化，可为后期腹腔内出血成像提供一维实验数据基础，我们采用向家兔腹膜下定量注射异体兔血的办法，制作了注血动物模型，并利用多频阻抗分析仪对腹部基础阻抗变化进行了测量，，分析了相关测量数据，验证了阻抗值随注血量增加而变化的规律，既而找出了不同频率对这种变化的影响。腹腔内注血动物模型的特点是动物较小，实验中容易控制。对家兔几乎
[Abstract]:Intraperitoneal hemorrhage usually occurs in some important organs of the abdomen, such as liver, spleen and so on. Due to many causes, such as impact, stab injury and post-operative bleeding, it has been effectively diagnosed. Guardianship is more difficult. Supported by the National Fund for Nature's key topic, "Electrical Impedance Image Monitoring Technology basic Research", EIT technology is non-invasive, dynamic imaging and sensitive to the characteristics of intraperitoneal hemorrhage. A series of studies on the problems related to intraperitoneal hemorrhage with electrical impedance monitoring have been carried out. A prototype of abdominal impedance imaging monitoring has been developed and can be used in experimental research. It is necessary to establish an appropriate animal model for EIT monitoring of abdominal hemorrhage, and to carry out monitoring experiments so as to further further study. In this context, a series of experimental studies are carried out as follows. 1) One-dimensional impedance measurement of intraperitoneal blood injection in rabbits The measurement of abdominal basic impedance during the early stage of intraperitoneal hemorrhage can provide one dimensional experimental data basis for later intraperitoneal hemorrhage imaging. We used the method of injecting allogeneic rabbit blood into rabbit subperitoneum. The animal model of blood injection was made, and the changes of the basic impedance of abdomen were measured by multi-frequency impedance analyzer. The related data were analyzed, and the law of impedance changing with the increase of blood volume was verified. The effects of different frequencies on this change have been identified. The characteristic of intraperitoneal blood injection animal model is that the animal is small and easy to control in the experiment.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R319;R-332

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