基于Amira5.4对小脑核团重建和体积测量的研究及其意义

发布时间：2018-01-22 17:04

本文关键词： Amira 小脑核团体积测量火棉胶　出处：《中国临床解剖学杂志》2014年06期 　论文类型：期刊论文

【摘要】：目的构建小脑各核团(deep cerebellar nuclei,DCN)的三维空间可视化模型并对其体积进行测量,以明确各小脑核团体积的男女性别差异,为小脑各核团的定位、临床功能及性别差异性研究提供参考数据。方法利用Amira 5.4对12组小脑火棉胶切片图像数据进行小脑核团的三维重建,并对各核团体积进行测量,比较各核团左、右侧及男女性体积差异。结果三维模型显示小脑各核团结构清楚,形态分布及其与第四脑室(fourth ventricle,FV)的空间关系亦能够清晰的展示。在左、右侧体积对比,各核团均无显著差异(P0.05);男、女性别对比,齿状核(dentate nucleus,DN)的体积男性远大于女性,差异有统计学意义(P0.001),而另外3组核团的体积没有明显的男女性别差异(P0.05)。结论对小脑核团的三维重建及体积测量可以明确各核团的形态、体积及其与第四脑室的空间关系,同时齿状核体积的男、女性别差异又为核团功能的进一步研究提供一定的参考价值。
[Abstract]:Objective to construct the cerebellar nuclei (deep, cerebellar nuclei, DCN) of the 3D visualization model and to measure its volume, to clarify the gender differences in cerebellar nucleus volume, as the cerebellar nucleus and provide reference data for research on the differences between clinical and functional sex. 3D reconstruction method using Amira 5.4 to 12 group of cerebellar celloidin section image data of cerebellar nuclei, and the measurement of the volume of the nucleus, nucleus of left, right and female volume. The differences display three-dimensional model of the cerebellar nuclei of clear structure, distribution and morphology of fourth ventricle (fourth, ventricle, FV) the spatial relationship can also clear the display on the left and right volume comparison, there was no significant difference among the nuclei (P0.05); male, female, dentate nucleus (dentate nucleus, DN) the volume of men far more than women, the difference was statistically significant (P0.001), While the other 3 groups of nucleus volume no significant difference between the male and female (P0.05). Three dimensional reconstruction and volume measurement of conclusion cerebellar nuclei can clear the nuclei of the form, and the fourth ventricle volume and its spatial relationship, and dentate nucleus volume of male, provide some reference value for further research of gender differences as the nucleus function.

【作者单位】：天津医科大学解剖学与组织胚胎学系;
【基金】：天津医科大学重点学科项目资助(No.052-200010)
【分类号】：R322
【正文快照】： 近些年,越来越多的临床和动物实验研究表明小脑核团在与之相关的临床治疗中有着重要的作用,例如,电刺激核团相关治疗、小脑立体定向手术等[1,2]。但是,对于各组小脑核团的准确定位及毗邻关系却仍然存在着许多问题。从临床应用来说,对小脑核团的研究多基于影像学资料,受限于分

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