基于HLA等位基因频率的全球人群亲缘关系初探

发布时间：2018-02-13 07:21

本文关键词： 人类白细胞抗原等位基因频率免疫遗传学群体遗传学　出处：《东南大学学报(医学版)》2014年04期 　论文类型：期刊论文

【摘要】：目的:探讨不同实验方法、不同统计方法的HLA配型数据在分析全球人群亲缘关系中的作用和效能,为运用HLA基因的多态性分析全球人群的遗传关系提供理论依据。方法:收集了全球6大洲10个地理分区中的110个人群HLA-A,-B和-DRB1座位的高分辨率配型数据,并对这些等位基因命名进行了归一化处理,用统一的统计方法重新统计了各人群的等位基因频率,用N-J法构建了全球人群的关系树,进而对全球人群间的亲缘关系进行了初步分析。结果:同一地理区域内的人群相互聚类,不同区域间的人群完全分离。关系树不仅能很好地分析局部地区相似人群的异同,也能有效地分析全球各区域人群间的亲缘关系。结论:HLA基因的多态性适合对全球人群的亲缘关系进行研究,也是一种高效的研究人类学的分子标记物。
[Abstract]:Objective: to explore the role and efficacy of HLA matching data of different experimental methods and different statistical methods in the analysis of genetic relationships in global population. Methods: the high resolution matching data of HLA-An B and DRB1 loci in 110 populations from 10 geographical regions of 6 continents were collected. The allele nomenclature is normalized, the allele frequency of each population is recounted by unified statistical method, and the relationship tree of global population is constructed by N-J method. The relationship tree can not only analyze the similarities and differences of similar populations in local areas, but also cluster each other in the same geographical area. Conclusion the polymorphism of the HLA gene is suitable for the study of the genetic relationship of the global population and is also an effective molecular marker for anthropological research.
【作者单位】： "发育与疾病相关基因"教育部重点实验室东南大学生命科学研究院;
【基金】：国家杰出青年基金资助项目(30325017)
【分类号】：R394

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