血管活性肠肽对树突状细胞趋化活性及细胞因子分泌的调节作用

发布时间：2018-03-12 11:46

本文选题：血管活性肠肽　切入点：树突状细胞　出处：《浙江大学》2006年硕士论文　论文类型：学位论文

【摘要】：树突状细胞(DC)是体内抗原提呈功能最强的抗原提呈细胞(APC),在诱导免疫应答中起着非常关键的作用。DC表达高水平的MHC分子、共刺激分子、粘附分子和Th1型细胞因子等,是已知唯一能活化初始T、B细胞的抗原提呈细胞。骨髓来源的DC前体细胞通过血流几乎能到达所有的组织,成为定居的未成熟DC(iDC),监视外来的抗原。当捕获抗原后,DC通过输入淋巴管从外周组织迁移到二级淋巴器官,启动特异性免疫应答。在迁移过程中,iDC经历表型和功能成熟,尤其是DC表面趋化因子受体的表达及对不同趋化因子的趋化活性改变,与DC的成熟阶段和功能活化紧密相关。iDC表达许多炎症性趋化因子受体,如CCR1、CCR2、CCR5和CCR6,能与许多CC和CXC趋化因子结合,如MIP-1α、MIP-1β、RANTES和MIP-3α,有利于iDC向炎症部位聚集。当DC成熟时,炎症性趋化因子受体表达下调或活性减低,对这些趋化因子中的大多数失去了应答能力,同时上调趋化因子受体CCR7的表达,其配体为表达于次级淋巴组织的MIP-3β和6Ckine,这些因素促使成熟DC(mDC)离开炎症部位,向淋巴组织迁移完成抗原提呈功能。有研究表明,CCR1和CCR5及其配体在iDC迁移到炎症部位中起着重要的作用;而CCR7与MIP-3β的相互作用则是mDC
[Abstract]:Dendritic cell (DC) is the most potent antigen presenting cell in vivo, which plays a key role in inducing immune response. DC expresses high level of MHC molecules, costimulatory molecules, adhesion molecules and Th1 type cytokines. Is the only antigen presenting cell known to activate the initial TGB cells. DC progenitor cells derived from bone marrow can reach almost all tissues through blood flow. When the antigen is captured, the DC migrates from the peripheral tissue to the secondary lymphoid organ, and initiates a specific immune response. During the migration, the DC experiences phenotypic and functional maturation. In particular, the expression of chemokine receptors and the changes of chemokine activity on the surface of DCs are closely related to the mature stage and functional activation of DC. IDC expresses many inflammatory chemokine receptors. For example, CCR1, CCR2, CCR5 and CCR6 can bind to many CC and CXC chemokines, such as MIP-1 伪 -MIP-1 尾 -RANTES and MIP-3 伪, which is conducive to the aggregation of iDC to the inflammatory site. When DC matures, the expression of inflammatory chemokine receptors is down-regulated or the activity decreases. Most of these chemokines lost their ability to respond, and up-regulated the expression of chemokine receptor CCR7, the ligand of which were MIP-3 尾 and 6Ckinein expressed in secondary lymphoid tissues, which caused the mature DCM to leave the inflammatory site. Migration to lymphoid tissues completes antigen presentation. Studies have shown that CCR1, CCR5 and their ligands play an important role in the migration of iDC to the inflammatory site, while the interaction between CCR7 and MIP-3 尾 is mDC.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R392

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