腺病毒感染及胞内运输途径的研究进展

发布时间：2018-03-17 03:02

本文选题：腺病毒　切入点：胞吞　出处：《生物工程学报》2014年06期 　论文类型：期刊论文

【摘要】：目前关于腺病毒感染及胞内运输的分子机制研究主要来源于C亚群腺病毒在肿瘤细胞系中的研究结果。腺病毒对靶细胞的感染及胞内运输大致分为几步:病毒与细胞表面受体的特异结合,胞吞介导的病毒内化,病毒逃脱胞内体进入细胞质,病毒沿着微管运输至核孔,病毒基因组入核。病毒胞内运输效率极高,感染后1 h,80%以上的病毒基因组被送至核内。但是腺病毒胞内的运输方式会因以下几个因素变化而产生差异:靶细胞类型,细胞生理状态,病毒血清型。文中对腺病毒感染靶细胞及胞内运输的已有分子机制进行综述,为临床基因治疗用途的病毒载体研发提供思路。
[Abstract]:At present, the molecular mechanism of adenovirus infection and intracellular transport is mainly derived from the results of subgroup C adenovirus in tumor cell lines. The infection of adenovirus against target cells and its intracellular transport are divided into several steps: virus and cytosolic transport. The specific binding of cell surface receptors, Endocytose-mediated virus internalization, virus escape from the intracellular body into the cytoplasm, virus transport along the microtubules to the nuclear pore, virus genome into the nucleus. More than 80% of the viral genome was sent to the nucleus at 1 hour after infection. However, the intracellular transport modes of adenovirus varied due to the following factors: the type of target cell, the physiological state of the cell. In this paper, the existing molecular mechanisms of adenovirus infection in target cells and intracellular transport are reviewed, which provides ideas for the research and development of viral vectors for clinical gene therapy.
【作者单位】：广东药学院生命科学与生物制药学院;广东省生物技术候选药物研究重点实验室;
【基金】：科技部“重大新药创制”科技重大专项“十一五”计划项目(No.2009ZX09103-708) 国家自然科学基金(Nos.31100664,31300737,81303292) 东莞市科技计划项目(No.2011105102027)资助~~
【分类号】：R363

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