人高迁移率族蛋白1的克

发布时间：2018-03-17 13:21

本文选题：人高迁移率族蛋白1　切入点：脓毒症　出处：《第一军医大学》2005年硕士论文　论文类型：学位论文

【摘要】：研究的目的和意义脓毒症(sepsis)指由感染引起的全身炎症反应综合征(systemic inflammatory response syndrome,SIRS),是各种严重创伤、烧伤、缺氧、再灌注损伤及外科大手术后常见的并发症,进一步发展可导致脓毒性休克、多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS),是当前创伤外科面临的棘手难题,已成为临床危重患者的重要死因之一。近十年来,随着炎症反应机制研究的不断深入,人们对于脓毒症的本质与病理过程有了进一步的理解,即认识到脓毒症、严重脓毒症、脓毒性休克及MODS是反映体内一系列病理生理改变及临床病情严重程度变化的动态过程,实质是机体全身炎症反应不断加剧、持续恶化的结果。严重创伤可以诱发初期的炎症反应,但由于机体产生的多种炎症介质所形成的级联效应,可使炎症反应扩大甚至失去控制,最终导致以细胞自身性破坏为特征的全身性炎症反应。过去普遍认为“早期”炎症介质如TNF-a和IL-1是引起多器官损害和死亡的“核心因子”,然而TNF-a和IL-1受体拮抗剂的临床应用并未取得明显效果。脓毒症后期,虽然患者病情持续加重直至死亡,但是TNF-a和IL-1水平往往已恢复至正常。这提示人们,可能存在某些晚期炎症介质参与了脓毒症后期的病理生理过程。 1999年,Wang等首次报道高迁移率族蛋白1(high mobility group box-1
[Abstract]:The purpose and significance of the study. Sepsis (sepsis) refers to systemic inflammatory response syndrome caused by infection. It is a common complication of severe trauma, burn, hypoxia, reperfusion injury and major surgery, which can lead to septic shock. Multiple organ dysfunction syndrome (MODS) is a difficult problem in trauma surgery and has become one of the most important causes of death in critically ill patients. There is a further understanding of the nature and pathological process of sepsis, that is, it is recognized that sepsis, severe sepsis, septic shock and MODS are dynamic processes reflecting a series of pathophysiological changes and changes in the severity of clinical conditions in the body. The essence is the result of the continuous worsening of the systemic inflammatory response. Severe trauma can induce the initial inflammatory reaction, but because of the cascade effect of various inflammatory mediators produced by the body, Can cause inflammation to expand or even get out of control, "early" inflammatory mediators such as TNF-a and IL-1 were considered to be "core factors" leading to multiple organ damage and death, whereas TNF-a and IL-1 receptor antagonists. No significant effect has been achieved in clinical application of sepsis in the later stage of sepsis. Although the patient's condition continues to worsen until death, the levels of TNF-a and IL-1 often return to normal, which suggests that some late inflammatory mediators may be involved in the pathophysiological process of late sepsis. In 1999, Wang et al reported for the first time high mobility group box-1 of high mobility group protein 1.
【学位授予单位】：第一军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R363

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