益生菌与肠黏膜互作的分子机制研究进展

发布时间：2018-03-26 08:19

本文选题：益生菌　切入点：肠道菌群　出处：《中国微生态学杂志》2014年03期

【摘要】：益生菌是一类定植于动物肠道,可辅助动物消化功能,维护肠道菌群平衡并可影响肠道免疫系统,有益于动物健康的重要调节性菌群。该类菌群与动物肠上皮细胞间互作的分子机制包括菌体表面分子如磷脂壁酸(phosphatidic acid,LTA)、表面层蛋白(S layer protein)等与宿主的粘附相关蛋白分子结合,通过占位效应抑制有害菌群在肠道内的定植;益生菌还可刺激肠道细胞分泌β防御素2、细菌素和有机酸等可抑制甚至杀灭有害菌群;在益生菌作用下,肠道上皮细胞可增强粘液糖蛋白、紧密连接蛋白occludin和ZO-1等分子的表达,加厚并加固肠道黏膜屏障;益生菌相关抗原可通过与抗原递呈细胞表面模式识别受体(TLRs等)分子结合,激活递呈细胞,启动各免疫细胞的交互作用,调节肠道免疫状态。
[Abstract]:Probiotics are a class of bacteria that are colonized in the gut of animals, which can assist the digestive function of animals, maintain the balance of the intestinal flora, and affect the intestinal immune system. The molecular mechanisms of the interaction between these bacteria groups and intestinal epithelial cells include the binding of cell surface molecules such as phosphatidic acid phosphatidic acid (LTAA) and surface layer protein (S layer protein) to host adhesion proteins. In addition, probiotics can stimulate intestinal cells to secrete 尾 -defensin 2, bacteriocin and organic acids can inhibit or even kill harmful flora. Intestinal epithelial cells can enhance the expression of mucoglycoprotein, tight junction protein (occludin) and ZO-1, and strengthen the intestinal mucosal barrier. Probiotic antigens can be combined with antigen-presenting cell surface pattern recognition receptor (TLRs). Activation of presenting cells, activation of the interaction of various immune cells, regulation of intestinal immune state.
【作者单位】：太原市万柏林区妇幼卫生站;北京大北农科技集团股份有限公司饲用微生物工程国家重点实验室;
【基金】：国家973计划资助项目(2012CB723702)
【分类号】：R378

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