腹主动脉及下腔静脉暂时性阻断、阿霉素隔离循环灌注的动物实验研究

发布时间：2018-03-30 13:07

本文选题：腹主动脉及下腔静脉　切入点：暂时性阻断　出处：《四川大学》2006年博士论文

【摘要】：研究目的：本研究采用动物实验的方法，将腹主动脉及下腔静脉暂时性阻断，在阻断部位下方以转流泵为动力，形成下腔静脉—转流泵—腹主动脉—组织—下腔静脉的人工循环，建立大白鼠腹主动脉及下腔静脉暂时性阻断隔离循环灌注动物模型；探讨腹主动脉下腔静脉暂时性阻断隔离循环灌注时间对鼠心率、呼吸，动脉压、血生化、肝肾脏功能、隔离灌注区肢体功能及健康状况的影响；研究腹主动脉及下腔静脉暂时性阻断隔离循环灌注下，ADM循环灌注的药代动力学特征；了解腹主动脉及下腔静脉暂时性阻断、ADM隔离循环灌注化疗对骨髓有核细胞凋亡、增殖的影响。本研究主要包括以下三个部分：一．腹主动脉及下腔静脉暂时性阻断、半身隔离循环灌注大鼠模型的建立二．腹主动脉及下腔静脉暂时性阻断、ADM隔离循环灌注大鼠的药代动力学
[Abstract]:Objective: in this study, the abdominal aorta and inferior vena cava were temporarily blocked by animal experiment, and the pump was used as the driving force. Artificial circulation of inferior vena cava, bypass pump, abdominal aorta, tissue and inferior vena cava was formed to establish the animal model of isolated circulation perfusion by temporary blocking of abdominal aorta and inferior vena cava in rats. To investigate the effects of temporary occlusion of inferior aortic vena cava (IVC) on heart rate, respiration, arterial pressure, blood biochemistry, liver and kidney function, limb function and health status of rats. To study the pharmacokinetic characteristics of ADM circulatory perfusion in abdominal aorta and inferior vena cava (IVC), and to investigate the apoptosis of bone marrow nucleated cells induced by ADM isolated circulation infusion chemotherapy. The effect of proliferation. This research mainly includes the following three parts:. 1. Establishment of a rat model of temporary occlusion of abdominal aorta and inferior vena cava and hemispheres isolated circulation perfusion. 2. Pharmacokinetics of isolated circulatory perfusion of ADM by temporary occlusion of abdominal aorta and inferior vena cava in rats
【学位授予单位】：四川大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R-332

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