Leptin对生长激素细胞GH分泌的影响及其机制的研究

发布时间：2018-04-09 12:33

本文选题：leptin　切入点：leptin受体　出处：《第四军医大学》2005年博士论文

【摘要】：生长激素(growth hormone,GH)是调节机体生长、发育、代谢和免疫功能的重要激素,其分泌紊乱与营养不良、肥胖以及糖尿病等临床疾病密切相关。影响垂体前叶生长激素的合成与分泌的因素很多,如下丘脑分泌的生长激素释放激素(GH-releasing hormone,GHRH)和生长抑素(somatostatin,SS),当下丘脑分泌的SS减少或GHRH分泌过多,长期刺激垂体可使之增生或形成腺瘤。另外,体外合成的生长激素释放肽(GH-releasing peptides,GHRP)及内源性的GHRP(ghrelin)都对GH的合成与分泌有重要的调节作用。有研究还发现许多神经递质、细胞因子及一些外周物质对GH的合成分泌也有调节作用。现有资料表明,垂体局部可产生很多分子较小的神经肽、生长因子或细胞因子等生物活性肽。这些活性肽通过旁分泌或自分泌作用,既能调节垂体前叶细胞的分化、发育和成熟,也能调节细胞的功能。它们在垂体内形成一个信息网,可以整合来自中枢及外周的信息,在垂体水平对GH的分泌、合成、调控发挥重要作用。 leptin是由167个氨基酸构成的蛋白质,由肥胖基因(obese gene,ob
[Abstract]:Growth hormone growth hormone (GH) is an important hormone that regulates the growth, development, metabolism and immune function of the body. Its secretion disorder is closely related to malnutrition, obesity, diabetes and other clinical diseases.There are many factors that influence the synthesis and secretion of growth hormone in anterior pituitary lobe, such as GH-releasing hormone GHRH of hypothalamus and somatostatin of somatostatin, when the SS secretion of hypothalamus decreases or GHRH secretion is excessive.Long-term stimulation of the pituitary gland may cause it to proliferate or form adenoma.In addition, growth hormone releasing peptide (GH-releasing peptide) and endogenous growth hormone (GHRP) can regulate the synthesis and secretion of GH in vitro.It has also been found that many neurotransmitters, cytokines and some peripheral substances also regulate the synthesis and secretion of GH.The available data show that many bioactive peptides such as neuropeptides, growth factors or cytokines can be produced locally in the pituitary gland.These active peptides can regulate the differentiation, development and maturation of anterior pituitary cells by paracrine or autocrine.They form an information network in the pituitary gland which can integrate the information from the central and peripheral areas and play an important role in the secretion synthesis and regulation of GH at the pituitary level.Leptin is a protein consisting of 167 amino acids.
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R33

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