种群免疫系统模型的研究

发布时间：2018-04-10 20:39

本文选题：免疫系统 + Penna模型　；参考：《大连理工大学》2007年硕士论文

【摘要】： 免疫学是当前生命科学研究的热点。免疫系统是一个复杂的自适应系统，可以保护生物体不受外部病原体侵害。应用数学模型对免疫系统进行研究，能够加深我们对于免疫系统的进一步了解和认识。通过把免疫系统研究中的形态空间模型和生物种群研究中的Penna模型结合到一起，本文研究了种群免疫领域的一些问题，并对其进行了探讨。下面将本文的所做的工作以及主要结论介绍如下：首先，本文对于生物免疫系统的组成、结构、机制及其性质等问题进行了较为全面的综述。讨论了免疫系统是如何保护生物体、免疫系统是如何快速进化、以及免疫系统的复杂性等相关问题。其次，文本从生物学角度介绍了模拟研究免疫系统的几种方法，其中包括：形态空间模型、元胞自动机模型，多agent模型等等。详细的介绍了免疫系统模型的发展过程，各种不同模型的特点及其应用。再次，通过把免疫系统中的形态空间模型以及修改了的Penna种群演化模型相结合，文本研究了种群免疫过程中相关问题。在本文中，种群中的个体信息由基本的Penna模型进行捕述，每个个体的免疫系统由形态空间模型进行描述。在Penna模型的基础上，，本文规定了个体的死亡(先天疾病、后天病死、老死)、繁殖、感染和免疫等规则。进而，本文对于免疫系统的记忆性、快速进化性以及疫苗在生物种群数量上的影响作用进行了研究。最后，我们给出了种群免疫模型的研究结论。我们发现在存在病毒影响的情况下，免疫系统的记忆性、快速进化性以及疫苗对于维持种群数目起到了重要的作用，是生物体不可或缺的一道屏障。
[Abstract]:Immunology is the focus of life science research.The immune system is a complex adaptive system that protects organisms from external pathogens.The application of mathematical models to the study of the immune system can deepen our understanding of the immune system.By combining the morphological space model in immune system research with the Penna model in biological population research, this paper studies some problems in the field of population immunization and discusses them.The work done and the main conclusions of this article are described below:Firstly, the composition, structure, mechanism and properties of biological immune system are reviewed.This paper discusses how the immune system protects organisms, how the immune system evolves rapidly, and the complexity of the immune system.Secondly, several methods of simulating immune system are introduced from the biological point of view, including morphological space model, cellular automata model, multiple agent model and so on.The development process of immune system model, the characteristics of different models and their applications are introduced in detail.Thirdly, by combining the morphological space model of immune system with the modified Penna population evolution model, the paper studies the related problems in the process of population immunization.In this paper, the individual information in the population is captured by the basic Penna model, and the immune system of each individual is described by the morphological space model.On the basis of Penna model, the rules of individual death (congenital disease, acquired disease, old death, reproduction, infection and immunity) are defined in this paper.Furthermore, the memory, rapid evolution of immune system and the effect of vaccine on population size were studied.Finally, we give the conclusion of the population immune model.We found that the memory, rapid evolution and vaccine of the immune system play an important role in maintaining the population number in the presence of virus, which is an indispensable barrier for organisms.
【学位授予单位】：大连理工大学
【学位级别】：硕士
【学位授予年份】：2007
【分类号】：R392

【引证文献】