比较嵌段共聚物微泡与脂质微泡造影剂的体外稳定性及体内超声造影效果

发布时间：2018-04-11 17:28

本文选题：造影剂 + 嵌段共聚物　；参考：《中国介入影像与治疗学》2014年04期

【摘要】：目的比较嵌段共聚物微泡造影剂与脂质微泡造影剂的体外稳定性及体内CEUS效果。方法采用单乳化法制备以mPEG-PLLA为外壳、包裹液态氟碳全氟戊烷的嵌段共聚物微泡造影剂,以机械振荡法制备脂质微泡造影剂,比较两种造影剂在体外随时间延长微泡数量的变化情况;经静脉团注造影剂进行新西兰大白兔肝脏造影,比较两种造影剂的始增时间、达峰时间、峰值强度、廓清时间等参数的差异。结果嵌段共聚物微泡造影剂稳定性明显高于脂质微泡造影剂,静置24h后微泡数量明显高于脂质微泡。兔肝CEUS结果显示,嵌段共聚物微泡造影与脂质微泡造影剂在低机械指数CEUS模式下均可明显增强,二者各项CEUS参数差异无统计学意义。结论嵌段共聚物微泡造影剂稳定性高于脂质微泡造影剂,用于兔体内CEUS可明显增强,可视为一种新型高分子微泡造影剂。
[Abstract]:Objective to compare the in vitro stability and in vivo CEUS effect of block copolymer microbubble contrast agent and lipid microbubble contrast agent.Methods the block copolymer microbubble contrast agent coated with liquid fluorocarbon perfluoropentane was prepared by single emulsification method, and lipid microbubble contrast agent was prepared by mechanical oscillation method.The difference of clearance time and other parameters.Results the stability of block copolymer microbubble contrast agent was significantly higher than that of lipid microbubble contrast agent.CEUS results of rabbit liver showed that both block copolymer microbubble angiography and lipid microbubble contrast agent were significantly enhanced in low mechanical index (CEUS) mode. There was no significant difference in CEUS parameters between the two groups.Conclusion the stability of block copolymer microbubble contrast agent is higher than that of lipid microbubble contrast agent. CEUS in rabbit body can be enhanced obviously and can be regarded as a new polymer microbubble contrast agent.
【作者单位】：福建医科大学附属协和医院超声科;福建医科大学医学技术与工程学院影像系;
【基金】：福建省卫生厅医学创新课题(2012-CXB-15) 全国大学生创新创业训练计划项目(201310392022)
【分类号】：R-332;R445.1

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