瞬时受体电位香草酸亚型1介导疼痛及其调节机制

发布时间：2018-04-14 01:12

本文选题：瞬时受体电位香草酸亚型 + 疼痛　；参考：《国际口腔医学杂志》2014年01期

【摘要】：三叉神经主要司职牙体和口颌面部的本体感觉传导,其膜表面有较高水平的瞬时受体电位香草酸亚型(TRPV)1表达。TRPV1属于瞬时受体电位离子通道家族成员之一,具有阳离子选择性,一经激活,可在三叉神经节和背根神经节介导疼痛及其传导。神经肽、缓激肽、前列腺素、神经生长因子和5-羟色胺等可以通过TRPV1通道直接刺激神经的疼痛感受器,引起疼痛敏感。温度和酸碱度亦可能引起相似的TRPV1通道结构改变。TRPV1的调控机制复杂并表现在诸多层面上,从基因转录、翻译和修饰到受体亚型的形成等,这些机制一方面维持TRPV1通道正常的生理功能,一方面也是造成其通道功能异常进而引起疼痛的根源。本文就TRPV1介导疼痛的机制和TRPV1的分子调控机制等研究进展作一综述。
[Abstract]:The proprioceptive conduction of trigeminal nerve in dentin and oral and maxillofacial region, the membrane surface of which has a high level of transient receptor potential vanillic acid subtype TRPV1 expression. TRPV1 belongs to one of the members of the transient receptor potential ion channel family, and has cationic selectivity.Once activated, pain and its transmission can be mediated in the trigeminal and dorsal root ganglion.Neuropeptides, bradykinins, prostaglandins, nerve growth factors and serotonin can directly stimulate nerve pain receptors through TRPV1 channels, causing pain sensitivity.Temperature and pH may also cause similar structural changes in TRPV1 channels. The regulatory mechanisms of TRPV1 are complex and present on many levels, ranging from gene transcription, translation and modification to the formation of receptor subtypes.These mechanisms not only maintain the normal physiological function of TRPV1 channel, but also cause abnormal channel function and cause pain.In this review, the mechanism of pain mediated by TRPV1 and the molecular regulation of TRPV1 are reviewed.
【作者单位】：口腔疾病研究国家重点实验室华西口腔医院修复科(四川大学);
【基金】：四川省科技厅科技支撑计划基金(2010SZ0100)
【分类号】：R363

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