半胱氨酰白三烯受体在小鼠脑和肺组织生理及病理过程的表达

发布时间：2018-04-30 22:21

本文选题：半胱氨酰白三烯受体1和2 + mRNA表达　；参考：《浙江大学》2006年博士论文

【摘要】：半胱氨酰白三烯(cysteinyl leukotrienes,CysLTs,包括LTC_4,LTD_4,LTE_4)是花生四烯酸5-脂氧酶(5-lipoxygenase,5-LOX)的代谢产物。CysLTs是很强的炎症介质,参与多种炎症反应过程,如介导呼吸道平滑肌痉挛、微血管渗漏等病理反应。在中枢神经系统内,半胱氨酰白三烯参与许多疾病的发生、发展,如脑缺血、脑外伤、脑出血、脑肿瘤、脑脊髓炎、多发性硬化、癫痫以及衰老等。在脑外伤、脑肿瘤、脑缺血等病理状态下,脑内CysLTs产生增加,并参与血脑屏障破坏、脑水肿的发生。 CysLTs通过其受体发挥生理作用。目前,已经发现和克隆了两种半胱氨酰白三烯受体(cysteinyl leukotrienes receptors),即CysLT_1和CysLT_2受体,它们均为经典的7次跨膜G蛋白偶联受体。CysLT_1受体有多种拮抗剂,如zafirlukast、montelukast、tomelukast、pobilukast、pranlukast(ONO-1078)和MK-571,它们均能拮抗CysLTs引起的人支气管收缩。目前,已有部分拮抗剂在临床用于支气管哮喘的治疗。但是,CysLT_2受体只有非选择性拮抗剂Bay u9773、FPL55712。 CysLT_1受体分布在脾脏、肺、胎盘、小肠、表皮和支气管平滑肌等组织,以及单核淋巴细胞、巨噬细胞、肥大细胞、嗜酸性粒细胞、CD34~+细胞、中性粒
[Abstract]:Cysteinyl leukotrienes (CysLTs, including LTC4LTD4LTE4) is a metabolite of 5-lipoxygenase5-LOX (arachidonic acid 5-lipoxygenase5-LOX). CysLTs is a strong inflammatory medium and participates in various inflammatory reaction processes, such as airway smooth muscle spasm, microvessel leakage and so on. In the central nervous system, cysteinyl leukotriene is involved in the development of many diseases, such as cerebral ischemia, brain trauma, cerebral hemorrhage, brain tumors, encephalomyelitis, multiple sclerosis, epilepsy and aging. In the pathological state of brain injury, brain tumor and cerebral ischemia, the CysLTs production in the brain is increased, and it is involved in the destruction of blood-brain barrier and the occurrence of brain edema. CysLTs plays a physiological role through its receptors. Two cysteinyl leukotrienes receptor receptors, CysLT_1 and CysLT_2 receptors, have been identified and cloned. Both of them are classical transmembrane G protein-coupled receptors. CysLT1 receptors have many antagonists. For example, Zafirlukasta montelukasta tomelukasta pobilukasta pranlukasta ONO-1078) and MK-571 can antagonize the human bronchoconstriction induced by CysLTs. At present, some antagonists have been used in the treatment of bronchial asthma. But CysLT2 receptor was only nonselective antagonist Bay u9773 FPL55712. CysLT_1 receptors are distributed in spleen, lung, placenta, small intestine, epidermis and bronchial smooth muscle, as well as monocyte, macrophage, mast cell, eosinophilic granulocyte CD34 ~ cell, neutrophil
【学位授予单位】：浙江大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R33;R363

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