个体心理社会应激与血清可溶性Fas、FasL水平的相关性研究

发布时间：2018-05-04 15:13

本文选题：心理社会应激 + sFas　；参考：《浙江大学》2007年硕士论文

【摘要】： [目的]：探讨个体心理社会应激与血清可溶性Fas(sFas)、FasL水平的相关性。 [对象和方法]：1．研究对象：分为老年组和青年组，每组50人；老年组为某疗养院住院体检疗养老人，平均年龄为77.9±4.3岁；青年组均为健康青年志愿者，平均年龄为26.3±5.0岁。2．研究工具：(1)自编个人基本情况调查量表；(2)简易应对方式问卷(SCSQ)：(3)领悟社会支持量表(PSSS)；(4)中文版知觉心理压力量表(CPSS)；(5)症状自评量表(SCL90)；(6)血清sFas／FaSL浓度测定试剂盒。3．研究方法：在统一指导语的条件下，研究对象一次性完成调查问卷的填写。于完成问卷的同一天清晨抽取研究对象空腹静脉血2ml，离心后收集血清，测定血清sFas／FasL的浓度。血清sFas／FasL浓度测定采用双抗体夹心法(ELISA)。用SPSS13.0统计软件对实验数据进行统计分析。统计分析包括青年组与老年组知觉心理压力、应对方式、领悟社会支持测试结果比较；青年组与老年组血清sFas／FasL水平比较：分别对青年组和老年组的知觉心理压力、应对方式、领悟社会支持与血清sFas／FasL水平进行相关性性分析；老年组SCL90高分组与SCL90低分组sFas／FasL水平差异分析；老年组SCL90总分、积极应对总分与sFas／FasL水平相关分析及逐步回归分析。 [结果]：青年组较老年组知觉心理压力水平高：老年组血清sFas浓度比青年组高，，血清FasL浓度比青年组低；青年组心理社会应激相关因素与血清sFas／FasL水平没有显著相关性：老年组心理社会应激水平与血清sFas水平显著正相关，积极应对方式与血清sFas水平显著负相关。 [结论]：个体心理社会应激水平以及血清sFas／FasL水平与年龄因素有关，老年人的心理社会应激水平、应对方式与血清sFas水平具有显著相关性。
[Abstract]:Objective: to investigate the correlation between individual psycho-social stress and the level of serum soluble FassFas-FasL. [objects and methods]: 1. The subjects were divided into elderly group and young group with 50 persons in each group, the elderly group was inpatients with physical examination in a sanatorium with an average age of 77.9 卤4.3 years, and the young group were all healthy young volunteers with an average age of 26.3 卤5.0 years. Research tool: 1) Self-designed personal basic situation Survey scale / 2) A simple coping style questionnaire: SCSSS: 3) perceived Social support scale (PSSS5) symptom Checklist (SCL 90 / 6) Serum sFas/FaSL concentration Test Kit. 3. Methods: under the condition of unified instruction, the subjects completed the questionnaire in one-time. Fasting venous blood was drawn from the subjects in the morning of the same day. Serum was collected after centrifugation to determine the concentration of serum sFas/FasL. Serum sFas/FasL concentration was determined by double antibody sandwich method. The experimental data were analyzed by SPSS13.0 software. The statistical analysis included the comparison of perceived psychological pressure, coping style and perceived social support test results between the young group and the old group, the comparison of serum sFas/FasL level between the young group and the old group: the perceived psychological pressure and coping style of the young group and the old group, respectively. The relationship between perceived social support and serum sFas/FasL level; the difference of sFas/FasL level between the high score group of SCL90 and the low group of SCL90 in the elderly group; the total score of SCL90 in the elderly group; the correlation analysis of the total score of coping with the level of sFas/FasL and stepwise regression analysis. [results]: the level of perceptual psychological pressure in the young group was higher than that in the old group: the serum sFas concentration in the elderly group was higher than that in the young group, and the serum FasL concentration was lower than that in the young group. There was no significant correlation between psychosocial stress and serum sFas/FasL level in young group. There was a significant positive correlation between psychosocial stress level and serum sFas level in elderly group, and negative correlation between positive coping style and serum sFas level. Conclusion: the level of individual psycho-social stress and serum sFas/FasL level are related to age factors. The level of psycho-social stress and coping style are significantly correlated with serum sFas level in the elderly.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2007
【分类号】：R395

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