β-榄香烯抑制胶质瘤兔角膜移植模型血管生成的实验研究

发布时间：2018-05-05 20:17

  本文选题：β-榄香烯 + 胶质瘤　； 参考：《中国现代医学杂志》2014年14期

【摘要】：目的复制兔角膜移植瘤血管生成模型,检测β-榄香烯体内抗血管生成效应。方法裸鼠皮下种植人脑胶质瘤细胞系SHG44细胞,形成实体胶质瘤。将所得胶质瘤实体小块移植于兔角膜,复制角膜移植瘤血管生成模型。经兔耳缘静脉注射β-榄香烯,干预两周后应用Ⅷ因子相关抗原免疫组织化学染色及图像分析技术,检测移植胶质瘤组织内微血管密度变化。结果兔角膜移植瘤血管生成模型成功复制;β-榄香烯处理组移植胶质瘤微血管密度明显低于对照组。结论兔角膜血管生成模型是定量研究肿瘤血管生成的良好工具;β-榄香烯具有体内抗肿瘤血管生成作用。
[Abstract]:Objective to study the anti-angiogenesis effect of 尾-elemene in rabbit corneal transplantation tumor. Methods Human glioma cell line SHG44 was implanted subcutaneously in nude mice to form solid glioma. The grafts of glioma were transplanted into rabbit cornea and the angiogenesis model of corneal transplantation tumor was established. 尾 -elemene was injected intravenously through rabbit ear margin. After two weeks of intervention, the microvessel density in transplanted glioma tissue was detected by immunohistochemical staining of factor 鈪，

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