肝主疏泄对模型动物胆固醇浓度的影响

发布时间：2018-05-08 02:00

  本文选题：肝主疏泄 + 模型动物　； 参考：《江西中医药》2014年11期

【摘要】：目的:通过观察肝失疏泄状态下模型动物胆汁中胆固醇浓度的变化,探讨肝主疏泄对模型动物胆汁中胆固醇含量的影响,为"胆病从肝论治"提供实验依据。方法:选用健康雄性SD大鼠,采用CUMS以及单纯束缚的方法,对SD大鼠进行刺激后取胆汁检测胆汁中胆固醇含量,观察其变化规律。结果:与正常组比较,CUMS组有显著性差异(P0.05),正常组胆固醇含量显著低于CUMS组。与正常组比较,单纯束缚组没有显著性差异。结论:肝主疏泄功能失常会在一定程度上影响模型动物胆固醇浓度,在某种肝失疏泄的状态下胆汁中的胆固醇含量呈升高趋势。
[Abstract]:Objective: to observe the changes of cholesterol concentration in bile of model animal under the condition of liver loss and catharsis, and to explore the effect of liver control on cholesterol content in bile of model animal, so as to provide experimental basis for "treating gallbladder disease from liver". Methods: healthy male SD rats were selected. The bile samples were taken from SD rats after stimulation by CUMS and simple binding method to detect the cholesterol content in bile and observe the change of bile cholesterol content. Results: compared with the normal group, there was a significant difference between the CUMS group and the normal group (P 0.05), and the cholesterol content in the normal group was significantly lower than that in the CUMS group. There was no significant difference between the simple bound group and the normal group. Conclusion: the abnormal function of the liver can influence the cholesterol concentration of the model animal to some extent, and the cholesterol content in the bile increases under the condition of some liver loss.
【作者单位】： 贵阳中医学院;
【基金】：国家自然科学基金项目(81160418) 贵州省科技厅、贵阳中医学院联合基金项目(黔科合中药字[2010]LKZ7015号)
【分类号】：R-332;R228
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本文编号：1859438