肺炎支原体主要黏附蛋白的研究进展

发布时间：2018-05-09 09:43

本文选题：肺炎支原体 + 黏附蛋白　；参考：《现代生物医学进展》2014年19期

【摘要】：肺炎支原体(Mycoplasma pneumoniae,Mp)可引起呼吸道感染,是儿童社区获得性肺炎的常见致病菌,并且可导致多系统并发症。Mp尖端的黏附蛋白复合体与肺纤毛上皮细胞的黏附过程是其主要致病机制。P1、P30、P116等蛋白作为黏附复合体的主要成分,在感染过程中起到了关键作用。在缺失这些蛋白的突变株中,细胞结构异常,黏附能力、运动速度、致病性均表现出不同程度的下降。由于Mp生长缓慢,对营养要求苛刻,常规微生物分离培养不适用于临床快速诊断,目前亚洲地区Mp耐药率居高不下,Mp感染后又无特异性临床症状,使得临床工作中Mp感染的诊治常被延误。重组蛋白表达技术的出现,使得Mp主要蛋白可以应用在Mp诊断试剂盒和疫苗研发中,本文针对Mp主要黏附蛋白的基因结构、致病机制及其应用方面的最新研究进展进行综述。
[Abstract]:Mycoplasma pneumoniae MP) can cause respiratory tract infection and is a common pathogen of community acquired pneumonia in children. Moreover, the adhesion process between the Mp-tip adhesion protein complex and pulmonary ciliated epithelial cells is the main pathogenic mechanism. P1P30P116 and other proteins are the main components of the adhesion complex, and play a key role in the process of infection. In the mutant lacking these proteins, the cell structure abnormality, adhesion ability, movement speed and pathogenicity all showed different degrees of decline. Due to the slow growth of MP and strict nutritional requirements, conventional microbial isolation and culture is not suitable for rapid clinical diagnosis, and there are no specific clinical symptoms after the high rate of Mp-resistance in Asia. The diagnosis and treatment of MP infection in clinical work is often delayed. With the development of recombinant protein expression technology, the main protein of MP can be used in the research and development of MP diagnostic kit and vaccine. In this review, the gene structure, pathogenesis and application of MP major adhesion protein are reviewed.
【作者单位】：首都儿科研究所细菌研究室;
【基金】：北京市自然科学基金项目(7112019)
【分类号】：R375.2

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