脑电磁场及脑内源定位研究

发布时间：2018-05-14 13:42

本文选题：脑电正问题 + 脑电逆问题　；参考：《贵州大学》2007年硕士论文

【摘要】： 脑功能的研究是生命科学研究中的前沿领域之一，其中脑电源的探测在临床、康复、认知研究中占有重要地位。由于脑电信号可以通过无创检测得到，，因此对脑电信号的研究就成为脑研究的热点之一。根据头皮记录到的多道脑电信号反演人脑内部电活动源的信息，即脑电逆问题的研究是涉及到计算电磁场理论，生物医学工程及信息科学等跨学科的交叉性课题，正越来越多地受到国际学术界的重视，其研究成果将在探索人的感觉、认知过程及神经疾病诊断等方面具有重要作用。本论文是在研究了脑电正问题的基础上，主要进行了介质球模型中2~n极子电位的解析解的研究。本文的主要工作包括如下内容： 1．介绍脑电场的研究意义、方法及应用前景，脑电的发生机理，脑电问题中的基本电磁学理论及物理模型，脑内源定位问题的研究进展及临床应用。 2．在均匀导电球头模型中任意2~n极子电位的一般性解析解的基础上，建立介质球的头模型，研究2~n极子电位的解析解。 3．研究了新型等效源法，将该方法中的球形等效源法用于计算脑电场的电位分布。视激励源为偶极子，考虑介质球头模型的电容效应，给出真实电源在非均匀各向同性四层同心介质球壳模型中的电位。利用等效分布源理论推导出无界空间中任意偶极子源的球形等效源的正演理论公式。为高分辨脑电地形图技术中的重构皮层电位提供了一种方法。
[Abstract]:The study of brain function is one of the frontier fields in life science, in which the detection of brain power plays an important role in clinical, rehabilitation and cognitive research. Since EEG can be detected by noninvasive detection, the research of EEG has become one of the hotspots in brain research. According to the multi-channel EEG signals recorded in the scalp to retrieve the information of the source of electrical activity in the human brain, the research on the inverse problem of EEG is a cross-disciplinary subject involving the theory of computational electromagnetic field, biomedical engineering, information science, and so on. More and more attention is being paid to the international academic circles, and its research results will play an important role in exploring human feelings, cognitive processes and the diagnosis of neurological diseases. Based on the study of the forward problem of EEG, the analytical solution of 2n pole potential in the dielectric sphere model is studied in this paper. The main work of this paper includes the following: 1. This paper introduces the research significance, method and application prospect of EEG, the mechanism of EEG, the basic electromagnetics theory and physical model of EEG, the research progress and clinical application of brain endogenous localization. 2. On the basis of the general analytical solution of any 2n pole potential in the uniform conducting spherical model, the head model of the dielectric sphere is established, and the analytical solution of the 2n pole potential is studied. 3. The new equivalent source method is studied. The spherical equivalent source method is used to calculate the potential distribution of the brain electric field. Considering the capacitance effect of the dielectric spherical head model, the potential of the real power source in the inhomogeneous isotropic four-layer concentric spherical shell model is given. The forward theoretical formula of spherical equivalent source of arbitrary dipole source in unbounded space is derived by using the theory of equivalent distribution source. It provides a method for the reconstruction of cortical potential in high resolution electroencephalogram (EEG).
【学位授予单位】：贵州大学
【学位级别】：硕士
【学位授予年份】：2007
【分类号】：R35

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