VGLUT1在大鼠Vme神经元内的表达及三叉神经本体觉传导通路的形态学研究

发布时间：2018-05-31 22:31

本文选题：VGLUT1 + 大鼠　；参考：《第四军医大学》2006年博士论文

【摘要】：三叉神经本体觉对于维持下颌运动的协调至为关键。研究三叉本体觉信息调控运动的直接和间接反射环路，以及向小脑或大脑传导的通路具有重要意义。然而，有关三叉神经本体觉的传导通路和局部反射环路，到目前为止仍不清楚。口面部本体觉初级传入神经元位于三叉神经中脑核(mesencephalic trigeminal nucleus，Vme)，在过去的30年，本教研室对大鼠Vme向丘脑的传导通路进行了大量的研究，发现传递口面部本体感觉信息的中枢通路为存在于 Vme 和丘脑腹后内侧核(ventral posteromedial nucleus,VPM)之间的分别由三级(“三级通路”)和四级(“四级通路”)神经元组成的两条平行通路。其中组成“三级通路”的核团依次为Vme、三叉神经感觉主核背内侧部(Vpdm)和丘脑VPM；组成“四级通路”的核团依次为Vme、三叉神经脊束核吻侧亚核背内侧部及其邻接的外侧网状结构(Vodm-LRF)、“带状区”[包括三叉上核的尾外侧部(Vsup-CL)、Vpdm、三叉神经运动核腹侧部(AVM)和位于上橄榄核背侧部(ADO)]以及丘脑VPM。但由于方法学的限制，，“四级通路”一直未被广泛认可。近年来已经证明的囊泡膜谷氨酸转运体有三种亚型，分别被命名为VGLUT1、VGLUT2和VGLUT3。VGLUT1和VGLUT2已被作为谷氨酸能神经元特异的标识物。在脊髓和延髓背角内，VGLUT1在所有的有髓初级传入纤维的终末内均表达。 CTb可以较好地跨节追踪粗的有髓初级传入纤维的中枢突(CA)和其
[Abstract]:Trigeminal proprioception is essential to maintain the coordination of mandibular movement. It is of great significance to study the direct and indirect reflex loop of trigeminal proprioceptive information and the pathway to the cerebellum or cerebellum. However, the conduction pathway and local reflex loop of trigeminal proprioception are still unclear. Primary afferent neurons of oral and facial proprioception are located in mesencephalic trigeminal nucleus of trigeminal nerve. In the past 30 years, the conduction pathway from Vme to thalamus in rats has been studied extensively. It was found that the central pathway for transmitting the proprioceptive information was composed of two parallel pathways between Vme and ventral posteromedial of the ventral medial thalamic nucleus (VPM), which were composed of three ("third pathway") and four (four) neurons, respectively. Vme, Vpdm of dorsal medial part of sensory nucleus of trigeminal nerve and VPMof thalamus were composed of "tertiary pathway", and Vme, dorsal medial part of rostral subnucleus of trigeminal nucleus of spinal tract and adjacent external nucleus of trigeminal spinal tract nucleus were composed of Vme, Vpdm and VPMs of thalamus, and Vme, dorsal medial part of rostral subnucleus of trigeminal spinal tract nucleus. Vodm-LRFA, "zonal region" (including Vsup-CLA Vpdm in the lateral caudal part of the superior trigeminal nucleus, AVM in the ventral part of the trigeminal motor nucleus) and in the dorsal part of the superior olivary nucleus (ADO), as well as the thalamus VPM. However, due to the limitations of methodology, the four-level pathway has not been widely recognized. In recent years, three subtypes of vesicular glutamate transporter, named VGLUT1, VGLUT2, VGLUT3.VGLUT1 and VGLUT2, have been identified as specific markers of glutamate neurons. VGLUT1 was expressed in the spinal cord and dorsal horn of medulla oblongata at the end of all myelinated primary afferent fibers. CTb can be used to track the central processes of the coarse myelinated primary afferent fibers across the ganglia.
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R322

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