激光耳显微外科动物模型的建立

发布时间：2018-06-02 13:37

本文选题：激光 + 耳显微外科　；参考：《中华耳科学杂志》2014年04期

【摘要】：目的重点探讨激光耳显微外科动物模型建立过程中如何选择最佳的麻醉方式、手术入路及激光种类。方法选用健康雄性听力正常的豚鼠70只,随机分为A组、B组及C组,其中A、B组各20只,C组30只,分别以速眠新、氯胺酮及复合麻醉,比较三组动物的存活率,并随机观察每组10只豚鼠麻醉后的苏醒时间,然后选用平对外耳道口的耳后入路打开听泡后壁暴露耳蜗底周和圆窗龛,采用CO2激光进行耳蜗底周造孔。结果 C组(复合麻醉组)动物存活率最高(pa′(0.0125)),且该组动物麻醉苏醒时间最短(31.50±7.47min),平对外耳道口的耳后入路损伤小、出血少,易于暴露耳蜗底周及圆窗龛,从而满足CO2激光耳蜗底周造孔的需要。结论在激光耳显微外科动物模型建立的过程中,复合麻醉是最佳的麻醉方式,平对外耳道口的耳后入路是最佳的术式,CO2激光是近年来研究的热点。
[Abstract]:Objective to discuss how to choose the best anesthetic method, operative approach and laser type in the establishment of animal model of laser ear microsurgery. Methods 70 healthy male guinea pigs with normal hearing were randomly divided into two groups: group A (n = 20) and group C (n = 30). The recovery time of 10 guinea pigs after anaesthesia was observed at random. Then the posterior wall of auditory vesicle was opened to expose the bottom circumference of cochlea and the circle window niche through the posterior ear approach of the external auditory meatus. CO2 laser was used to make the hole around the bottom of the cochlea. Results the survival rate of group C (compound anesthesia group) was the highest, and the recovery time of anesthesia in group C was 31.50 卤7.47 min. The injury to the posterior approach of external auditory meatus was small, the bleeding was less, and it was easy to expose the circumcochlear circumference and the circle window niche. So as to meet the need of CO2 laser cochlear basal foramination. Conclusion compound anesthesia is the best anaesthesia method in the process of establishing animal model of laser otoacoustic microsurgery, and the best method of CO _ 2 laser is to treat the external auditory meatus orifice with CO _ 2 laser in recent years.
【作者单位】：恩施土家族苗族自治州中心医院;福建医科大学省立临床医学院;
【基金】：国家自然科学基金资助项目(60878062) 卫生部科学研究基金福建省卫生教育联合攻关计划项目(WKJ 2008-2-35) 福建省自然科学基金(2011J01135)
【分类号】：R-332

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