发热温度调节树突状细胞表达TLR4及其介导的信号转导机制的研究

发布时间：2018-06-07 02:44

本文选题：树突状细胞 + 发热温度处理　；参考：《浙江大学》2005年博士论文

【摘要】：发热(fever)是一种复杂的生理反应,病理条件下的发热主要是由各种病原体感染引起的,如流感病毒、SARS病毒、肺炎球菌、伤寒杆菌等引起的发热。发热也可以由非感染性疾病引起,像中暑、恶性肿瘤、白血病等均可引起的发热。多种细胞因子参与发热的形成,IL-1β、IL-6、IL-8、IFN-γ,MIP-1a等内源性热源促进发热的形成;IL-10作为内源性抗热源则抑制发热的形成;根据实验体系不同,TNF-a则具有热源和抗热源的双重作用。目前认为,发热有助于宿主抵御细菌、真菌和病毒感染,提高受感染动物的存活率,缩短发病时间,加快病原体的清除过程。但对于其机制,目前了解并不多。近年来的研究表明,发热可从多个方面调节宿主的免疫应答,发热可增强体液和细胞免疫,发热可增强树突状细胞(dendritic cell,DC)的抗原递呈功能,促进皮肤郎格汉斯氏细胞迁移。此外,发热也可以促进淋巴细胞向次级淋巴组织归巢,促进中性粒细胞释放一氧化氮和氧代谢中间物,增强先天免疫功能,发热还可以调节LPS诱导的IL-12等多种细胞因子的分泌,提高受细菌感染小鼠的存活率。 Toll样受体(Toll-like receptors,TLRs)是一类重要的模式识别受体(Pattern recognition receptor,PRR),在识别微生物感染的过程中发挥重要的作用。Toll样受体识别病原体的一些高度保守的分子结构,即病原体相关
[Abstract]:Fever is a complex physiological response. Fever under pathological conditions is mainly caused by the infection of various pathogens, such as influenza virus SARS virus, pneumococcus, typhoid bacillus and so on. Fever can also be caused by non-infectious diseases such as heat stroke, malignant tumors, leukemia, etc. Many cytokines are involved in the formation of fever. The endogenous heat sources such as IL-1 尾 IL-6, IL-8, IFN- 纬 -MIP-1a, and so on, promote the formation of fever. As an endogenous anti-heat source, IL-10 inhibits the formation of fever, and according to the different experimental systems, TNF-a has the dual effects of heat source and anti-heat source. It is believed that fever can help the host resist bacterial, fungal and viral infections, improve the survival rate of infected animals, shorten the onset time, and speed up the process of pathogen clearance. However, little is known about its mechanism. Recent studies have shown that fever can regulate host immune response from many aspects, fever can enhance humoral and cellular immunity, fever can enhance the antigen-presenting function of dendritic cells (DC) and promote the migration of Langerhans cells in skin. In addition, fever can also promote lymphocyte homing to secondary lymphoid tissue, promote neutrophil release of nitric oxide and oxygen metabolic intermediates, enhance innate immune function, and regulate the secretion of IL-12 and other cytokines induced by LPS. To improve the survival rate of mice infected with bacteria. Toll-like receptor (TLRs) is an important pattern recognition receptor, which plays an important role in the identification of microbial infections. Toll-like receptors recognize some highly conserved molecular structures of pathogens, that is, pathogen-related.
【学位授予单位】：浙江大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R392

【引证文献】